Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evolution and epidemic spread of SARS-CoV-2 in Brazil

Full text
Author(s):
Show less -
Candido, Darlan S. [1, 2] ; Claro, Ingra M. [2, 3] ; de Jesus, Jaqueline G. [2, 3] ; Souza, William M. [4] ; Moreira, Filipe R. R. [5] ; Dellicour, Simon [6, 7] ; Mellan, Thomas A. [8] ; du Plessis, Louis [1] ; Pereira, Rafael H. M. [9] ; Sales, Flavia C. S. [2, 3] ; Manuli, Erika R. [2, 3] ; Theze, Julien [10] ; Almeida, Luiz [11] ; Menezes, Mariane T. [5] ; Voloch, Carolina M. [5] ; Fumagalli, Marcilio J. [4] ; Coletti, Thais M. [2, 3] ; Silva, Camila A. M. [2, 3] ; Ramundo, Mariana S. [2, 3] ; Amorim, Mariene R. [12] ; Hoeltgebaum, Henrique H. [13] ; Mishra, Swapnil [8] ; Gill, Mandev S. [7] ; Carvalho, Luiz M. [14] ; Buss, Lewis F. [2] ; Prete Jr, Carlos A. ; Ashworth, Jordan [15] ; Nakaya, I, Helder ; Peixoto, Pedro S. [16] ; Brady, Oliver J. [17, 18] ; Nicholls, Samuel M. [19] ; Tanuri, Amilcar [5] ; Rossi, Atila D. [5] ; Braga, V, Carlos K. ; Gerber, Alexandra L. [11] ; Guimaraes, Ana Paula de C. [11] ; Gaburo Jr, Nelson ; Alencar, Cecila Salete [20] ; Ferreira, Alessandro C. S. [21] ; Lima, Cristiano X. [22, 23] ; Levi, Jose Eduardo [24] ; Granato, Celso [25] ; Ferreira, Giulia M. [26] ; Francisco Jr, Ronaldo S. ; Granja, Fabiana [12, 27] ; Garcia, Marcia T. [28] ; Moretti, Maria Luiza [28] ; Perroud Jr, Mauricio W. ; Castineiras, Terezinha M. P. P. [29] ; Lazari, Carolina S. [30] ; Hill, Sarah C. [1, 31] ; de Souza Santos, Andreza Aruska [32] ; Simeoni, Camila L. [12] ; Forato, Julia [12] ; Sposito, Andrei C. [33] ; Schreiber, Angelica Z. [34] ; Santos, Magnun N. N. [34] ; de Sa, Camila Zolini [35] ; Souza, Renan P. [35] ; Resende-Moreira, Luciana C. [36] ; Teixeira, Mauro M. [37] ; Hubner, Josy [38] ; Leme, Patricia A. F. [39] ; Moreira, Rennan G. [40] ; Nogueira, Mauricio L. [41] ; Ferguson, Neil M. [8] ; Costa, Silvia F. [2, 3] ; Proenca-Modena, Jose Luiz [12] ; Vasconcelos, Ana Tereza R. [42] ; Bhatt, Samir [8] ; Lemey, Philippe [7] ; Wu, Chieh-Hsi [43] ; Rambaut, Andrew [44] ; Loman, Nick J. [19] ; Aguiar, Renato S. [35] ; Pybus, Oliver G. [1] ; Sabino, Ester C. [3] ; Faria, Nuno Rodrigues [2, 8] ; Discovery, Brazil-UK Ctr Arbovirus
Total Authors: 79
Affiliation:
Show less -
[1] Univ Oxford, Dept Zool, Oxford - England
[2] Univ Sao Paulo, Fac Med, Inst Med Trop, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Dept Molestias Infecciosas & Parasitaries, Sao Paulo - Brazil
[4] Fac Med Ribeirao Preto, Ctr Pesquisa Virol, Ribeirao Preto - Brazil
[5] Univ Fed Rio de Janeiro, Dept Genet, Inst Biol, Rio De Janeiro - Brazil
[6] Univ Libre Bruxelles, Spatial Epidemiol Lab, Brussels - Belgium
[7] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst, Leuven - Belgium
[8] Imperial Coll London, MRC Ctr Global Infect Dis Anal, J IDEA, London - England
[9] V, Inst Appl Econ Res, Brasilia, DF - Brazil
[10] Univ Clermont Auvergne, VetAgro Sup, INRAE, UMR EPIA, St Genes Champanelle - France
[11] Lab Bioinformat, Lab Natl Comp Cient, Petropolis - Brazil
[12] Univ Estadual Campinas, Dept Genet Evolucao Microbiol & Imunol, Inst Biol, Campinas - Brazil
[13] Imperial Coll London, Dept Math, London - England
[14] Fundacao Getalio Vargas, Escola Matemat Aplicada EMAp, Rio De Janeiro - Brazil
[15] Univ Edinburgh, Usher Inst, Edinburgh, Midlothian - Scotland
[16] Univ Sao Paulo, Inst Matemat & Estat, Dept Matemat Aplicada, Sao Paulo - Brazil
[17] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, Fac Epidemiol & Populat Hlth, London - England
[18] London Sch Hyg & Trop Med, Ctr Math Modelling Infect Dis, London - England
[19] Univ Birmingham, Inst Microbiol & Infect, Birmingham, W Midlands - England
[20] Univ Sao Paulo, LIM Lab Med Lab 03, Hosp Clin, Fac Med, Sao Paulo - Brazil
[21] Inst Hermes Pardini, Belo Horizonte, MG - Brazil
[22] Univ Fed Minas Gerais, Fac Med, Dept Cirurgia, Belo Horizonte, MG - Brazil
[23] Simile Inst Imunol Aplicada Ltda, Belo Horizonte, MG - Brazil
[24] Lab DASA, Sao Paulo - Brazil
[25] Lab Fleury, Sao Paulo - Brazil
[26] Univ Fed Uberlandia, Inst Glandes Biomed, Lab Virol, Uberlandia, MG - Brazil
[27] Univ Fed Roraima, Ctr Estudos Biodiversidade, Boa Vista, Parana - Brazil
[28] Univ Estadual Campinas, Fac Ciencias Med, Div Doences Infecciacas, Campinas, SP - Brazil
[29] Univ Fed Rio de Janeiro, Fac Med, Dept Doencas Infeccioses & Parasitarias, Rio De Janeiro - Brazil
[30] Univ Sao Paulo, Cent Hosp Clin, Fac Med, Div Lab, Sao Paulo - Brazil
[31] Royal Vet Coll, Dept Pathobiol & Populat Sci, Hatfield, Herts - England
[32] Univ Oxford, Latin Amer Ctr, Oxford Sch Global & Area Studies, Oxford - England
[33] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, Campinas, SP - Brazil
[34] Univ Estadual Campinas, Dept Patol, Fac Ciencias Med, Campinas, SP - Brazil
[35] Univ Fed Minas Gerais, Dept Genet Ecol & Evolucao, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[36] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bot, Belo Horizonte, MG - Brazil
[37] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Belo Horizonte, MG - Brazil
[38] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Celular, Belo Horizonte, MG - Brazil
[39] Univ Estadual Campinas, Ctr Saude Comunidade, Campinas, SP - Brazil
[40] Univ Fed Minas Gerais, Ctr Labs Multiusuarios, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[41] Fac Med Sao Jose do Rio Preto, Lab Pesquisas Virol, Sao Jose Do Rio Preto, SP - Brazil
[42] Francisco Jr, Jr., Ronaldo S., Lab Bioinformat, Lab Natl Comp Cient, Petropolis - Brazil
[43] Univ Southampton, Math Sci, Southampton, Hants - England
[44] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian - Scotland
Total Affiliations: 44
Document type: Journal article
Source: Science; v. 369, n. 6508, SI, p. 1255+, SEP 4 2020.
Web of Science Citations: 116
Abstract

Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data, assessments of the impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6 in Sao Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil. We estimate that most (76%) of the Brazilian strains fell in three clades that were introduced from Europe between 22 February and 11 March 2020. During the early epidemic phase, we found that SARS-CoV-2 spread mostly locally and within state borders. After this period, despite sharp decreases in air travel, we estimated multiple exportations from large urban centers that coincided with a 25% increase in average traveled distances in national flights. This study sheds new light on the epidemic transmission and evolutionary trajectories of SARS-CoV-2 lineages in Brazil and provides evidence that current interventions remain insufficient to keep virus transmission under control in this country. (AU)

FAPESP's process: 16/18445-7 - Numerical methods for the next generation weather and climate models
Grantee:Pedro da Silva Peixoto
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 18/17176-8 - Real-time, rapid detection and sequencing of arboviruses in Brazil: Zika, Dengue, Chikungunya and Yellow Fever
Grantee:Ingra Morales Claro
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/21301-5 - Flavivirus and Alphavirus identification in mosquitoes (Diptera: Culicidae) collected in the city of São Paulo
Grantee:Camila Alves Maia da Silva
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/09383-3 - Study about Flavivirus epitopes with medical importance in Brazil and its antibodies
Grantee:Marcilio Jorge Fumagalli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/25468-9 - Analysis of the human endogenous retrovirus in HTLV infected patients
Grantee:Flavia Cristina da Silva Sales
Support type: Scholarships in Brazil - Master
FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
Grantee:Ester Cerdeira Sabino
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/12000-1 - Modeling of the spatiotemporal dispersion of emergent arboviruses using heterogeneous data sources in the State of São Paulo
Grantee:Jaqueline Goes de Jesus
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 20/04558-0 - Characterization of intrinsic risk factors and the development of new diagnostic and treatment alternatives for COVID-19
Grantee:José Luiz Proença Módena
Support type: Regular Research Grants
FAPESP's process: 19/24251-9 - Multi-omic approaches for the study of Chikungunya disease
Grantee:William Marciel de Souza
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 19/07544-2 - Mosquito field collections and COI barcode identification using MinION technology
Grantee:Thaís de Moura Coletti
Support type: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 18/14933-2 - Integrative biology applied to human health
Grantee:Helder Takashi Imoto Nakaya
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 20/04836-0 - Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in São José do Rio Preto, SP, Brazil in 2020
Grantee:Maurício Lacerda Nogueira
Support type: Regular Research Grants
FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
Grantee:José Luiz Proença Módena
Support type: Research Grants - Young Investigators Grants