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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanotechnology approaches in the current therapy of skin cancer

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Neves Borgheti-Cardoso, Livia [1, 2, 3] ; Rosa Viegas, Juliana Santos [1] ; Pupo Silvestrini, Ana Vitoria [1] ; Caron, Angelo Luis [1] ; Praca, Fabiola Garcia [1] ; Kravicz, Marcelo [1] ; Lopes Badra Bentley, Maria Vitoria [1]
Total Authors: 7
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Av Cale S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Barcelona - Spain
[3] Univ Barcelona, Barcelona Inst Global Hlth, ISGlobal, Hosp Clin, Barcelona - Spain
Total Affiliations: 3
Document type: Review article
Source: Advanced Drug Delivery Reviews; v. 153, n. SI, p. 109-136, JAN 1 2020.
Web of Science Citations: 2

Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized. (c) 2020 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 19/04448-2 - Development of a nanostructured lipid carrier containing pool of siRNAs associated with the antitumor agent as a multifunctional therapeutic approach for skin Cancer
Grantee:Juliana dos Santos Rosa
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support type: Research Projects - Thematic Grants