Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study

Author(s):Show less -

Lariviere, Sara ^[1] ; Rodriguez-Cruces, Raul ^[1] ; Royer, Jessica ^[1] ; Caligiuri, Maria Eugenia ^[2] ; Gambardella, Antonio ^{[2, 3]} ; Concha, Luis ^[4] ; Keller, Simon S. ^{[5, 6]} ; Cendes, Fernando ^[7] ; Yasuda, Clarissa ^[7] ; Bonilha, Leonardo ^[8] ; Gleichgerrcht, Ezequiel ^[8] ; Focke, Niels K. ^[9] ; Domin, Martin ^[10] ; von Podewills, Felix ^[11] ; Langner, Soenke ^[12] ; Rummel, Christian ^[13] ; Wiest, Roland ^[13] ; Martin, Pascal ^[14] ; Kotikalapudi, Raviteja ^[14] ; O'Brien, Terence J. ^{[15, 16, 17]} ; Sinclair, Benjamin ^{[15, 16, 17]} ; Vivash, Lucy ^{[15, 16, 17]} ; Desmond, Patricia M. ^{[15, 17]} ; Alhusaini, Saud ^{[18, 19]} ; Doherty, Colin P. ^{[20, 21]} ; Cavalleri, Gianpiero L. ^{[18, 21]} ; Delanty, Norman ^{[18, 21]} ; Kalviainen, Reetta ^{[22, 23]} ; Jackson, Graeme D. ^[24] ; Kowalczyk, Magdalena ^[24] ; Mascalchi, Mario ^[25] ; Semmelroch, Mira ^[24] ; Thomas, Rhys H. ^[26] ; Soltanian-Zadeh, Hamid ^{[27, 28, 29]} ; Davoodi-Bojd, Esmaeil ^[30] ; Zhang, Junsong ^[31] ; Lenge, Matteo ^{[32, 33]} ; Guerrini, Renzo ^[32] ; Bartolini, Emanuele ^[34] ; Hamandi, Khalid ^{[35, 36]} ; Foley, Sonya ^[36] ; Weber, Bernd ^[37] ; Depondt, Chantal ^[38] ; Absil, Julie ^[39] ; Carr, Sarah J. A. ^[40] ; Abela, Eugenio ^[40] ; Richardson, Mark P. ^[40] ; Devinsky, Orrin ^[41] ; Severino, Mariasavina ^[42] ; Striano, Pasquale ^[42] ; Tortora, Domenico ^[42] ; Hatton, Sean N. ^[43] ; Vos, Sjoerd B. ^{[44, 45, 46]} ; Duncan, John S. ^{[44, 45]} ; Whelan, Christopher D. ^[18] ; Thompson, Paul M. ^[47] ; Sisodiya, Sanjay M. ^{[44, 45]} ; Bernasconi, Andrea ^[48] ; Labate, Angelo ^{[2, 3]} ; McDonald, Carrie R. ^[49] ; Bernasconi, Neda ^[48] ; Bernhardt, Boris C. ^[1]

Affiliation:Show less -

^[1] McGill Univ, Montreal Neurol Inst & Hosp, McConnell Brain Imaging Ctr, Multimodal Imaging & Connectome Anal Lab, Montreal, PQ - Canada

^[2] Magna Graecia Univ Catanzaro, Neurosci Res Ctr, Catanzaro, CZ - Italy

^[3] Magna Graecia Univ Catanzaro, Inst Neurol, Catanzaro, CZ - Italy

^[4] Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro - Mexico

^[5] Walton Ctr NHS Fdn Trust, Liverpool, Merseyside - England

^[6] Univ Liverpool, Inst Syst Mol & Integrat Biol, Liverpool, Merseyside - England

^[7] Univ Estadual Campinas, Dept Neurol, UNICAMP, Campinas, SP - Brazil

^[8] Med Univ South Carolina, Dept Neurol, Charleston, SC 29425 - USA

^[9] Univ Med Gottingen, Dept Clin Neurophysiol, Gottingen - Germany

^[10] Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, Funct Imaging Unit, Greifswald - Germany

^[11] Univ Med Greifswald, Dept Neurol, Greifswald - Germany

^[12] Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, Greifswald - Germany

^[13] Univ Hosp Bern, Univ Inst Diagnost & Intervent Neuroradiol, Support Ctr Adv Neuroimaging SCAN, Bern - Switzerland

^[14] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurol & Epileptol, Tubingen - Germany

^[15] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic - Australia

^[16] Monash Univ, Alfred Hosp, Cent Clin Sch, Dept Neurosci, Melbourne, Vic - Australia

^[17] Univ Melbourne, Royal Melbourne Hosp, Dept Radiol, Parkville, Vic - Australia

^[18] Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin - Ireland

^[19] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 - USA

^[20] St James Hosp, Dept Neurol, Dublin - Ireland

^[21] FutureNeuro SFI Res Ctr, Dublin - Ireland

^[22] Kuopio Univ Hosp, Epilepsy Ctr, Neuro Ctr, European Reference Network Rare & Complex Epileps, Kuopio - Finland

^[23] Univ Eastern Finland, Fac Hlth Sci, Sch Med, Inst Clin Med, Kuopio - Finland

^[24] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic 3010 - Australia

^[25] Univ Florence, Meyer Children Hosp Florence, Neuroradiol Res Program, Florence - Italy

^[26] Newcastle Univ, Transit & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear - England

^[27] Henry Ford Hlth Syst, Dept Radiol, Detroit, MI - USA

^[28] Univ Tehran, Contol & Intelligent Proc Ctr Excellence CIPCE, Sch Elect & Comp Engn, Tehran - Iran

^[29] Henry Ford Hlth Syst, Dept Res Adm, Detroit, MI - USA

^[30] Henry Ford Hlth Syst, Dept Neurol, Detroit, MI - USA

^[31] Xiamen Univ, Cognit Sci Dept, Xiamen - Peoples R China

^[32] Univ Florence, Childrens Hosp A Meyer, Neurosci Dept, Child Neurol Unit & Labs, Florence - Italy

^[33] Univ Florence, Neurosurg Dept, Funct & Epilepsy Neurosurg Unit, Childrens Hosp A Meyer, Florence - Italy

^[34] Nuovo Osped Santo Stefano, Neurol Unit, USL Ctr Toscana, Prato - Italy

^[35] Cardiff Univ, Cardiff Univ Brain Res Imaging Ctr CUBRIC, Coll Biomed Sci, Cardiff - Wales

^[36] Univ Hosp Wales, Dept Neurol, Welsh Epilepsy Unit, Cardiff - Wales

^[37] Univ Hosp Bonn, Inst Expt Epileptol & Cognit Res, Bonn - Germany

^[38] Univ Libre Bruxelles, Dept Neurol, Hop Erasme, Brussels - Belgium

^[39] Univ Libre Bruxelles, Dept Radiol, Hop Erasme, Brussels - Belgium

^[40] Kings Coll London, Inst Psychiat Psychol & Neurosci, Div Neurosci, London - England

^[41] NYU, Dept Neurol, Grossman Sch Med, New York, NY 10016 - USA

^[42] IRCCS, Ist Giannina Gaslini, Genoa - Italy

^[43] Univ Calif San Diego, Dept Neurosci, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 - USA

^[44] Chalfont Ctr Epilepsy, Gerrards Cross, Bucks - England

^[45] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London - England

^[46] UCL, Ctr Med Image Comp, London - England

^[47] USC Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Inst Neuroimaging & Informat, Los Angeles, CA - USA

^[48] McGill Univ, Montreal Neurol Inst & Hosp, McConnell Brain Imaging Ctr, Neuroimaging Epilepsy Lab, Montreal, PQ - Canada

^[49] Univ Calif San Diego, Dept Psychiat, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 - USA

• Document type: Journal article
• Source: SCIENCE ADVANCES; v. 6, n. 47 NOV 2020.
• Web of Science Citations: 0

Abstract

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies. (AU)

• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC