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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Protein glycosylation inLeishmaniaspp.

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Mule, Simon Ngao [1] ; Saad, Joyce Silva [1] ; Fernandes, Livia Rosa [1] ; Stolf, Beatriz S. [2] ; Cortez, Mauro [2] ; Palmisano, Giuseppe [1]
Total Authors: 6
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, GlycoProte Lab, Ave Lineu Prestes 1374, BR-05508000 Butanta, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: MOLECULAR OMICS; v. 16, n. 5, p. 407-424, OCT 1 2020.
Web of Science Citations: 0

Protein glycosylation is a co- and post-translational modification that, inLeishmaniaparasites, plays key roles in vector-parasite-vertebrate host interaction. In the mammalian host,Leishmaniaprotein glycosylation is involved in virulence, host cell invasion, and immune evasion and modulation. TheLeishmaniaglycocalyx is composed by a dense array of glycoconjugates including lipophosphoglycan, glycoinositolphospholipids, glycoproteins and proteophosphoglycans which varies in composition betweenLeishmaniaspecies and developmental stages. The current knowledge onLeishmaniaprotein glycosylation is quite limited. The development of novel analytical tools to characterize theLeishmaniaglycoproteome and the expanding toolbox to modulate the parasite glycocode will help in deciphering the processes involved inLeishmania-host interaction. This review will recapitulate the current knowledge ofLeishmaniaprotein glycosylation, and glycan structures reported, and the potential application of mass spectrometry-based analysis for system-wideLeishmaniaglycoproteome and glycome analysis. (AU)

FAPESP's process: 20/04923-0 - SARS-CoV-2 glycosylation: a blueprint structural insight for understanding COVID-19 pathogenesis
Grantee:Giuseppe Palmisano
Support type: Regular Research Grants
FAPESP's process: 18/15549-1 - Post-translational modifications in Chagas Disease biological processes and diagnostics: novel methodological approaches and biological applications
Grantee:Giuseppe Palmisano
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 16/23689-2 - Proteomic and post-translation modification characterization of Leishmanias L. (V.) braziliensis, L. (L.) amazonensis and L. (L.) chagasi using a shotgun protemics approaches.
Grantee:Joyce Silva Saad
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/04032-5 - Dissecting the pathogenesis of Chagas Disease by deep glycomics and glycoproteomics approaches
Grantee:Simon Ngao Mule
Support type: Scholarships in Brazil - Doctorate