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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics

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Nani, Joao V. [1, 2, 3] ; Lee, Richard S. [4] ; Yonamine, Camila M. [1, 2] ; Sant'Anna, Osvaldo A. [5] ; Juliano, Maria A. [6] ; Gadelha, Ary [3] ; Mari, Jair J. [3] ; Hayashi, Mirian A. F. [1, 2]
Total Authors: 8
[1] CNPq FAPESP CAPES, Natl Inst Translat Med INCT TM, Ribeirao Preto - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Farmacol, Escola Paulista Med EPM, Rua 3 Maio 100, 3rd Floor, BR-04044020 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Escola Paulista Med EPM, Sao Paulo - Brazil
[4] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD - USA
[5] Inst Butantan, Lab Immunochem, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo UNIFESP, Dept Biophys, Escola Paulista Med EPM, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 OCT 28 2020.
Web of Science Citations: 0

Nuclear distribution element-like 1 (NDEL1) enzyme activity is important for neuritogenesis, neuronal migration, and neurodevelopment. We reported previously lower NDEL1 enzyme activity in blood of treated first episode psychosis and chronic schizophrenia (SCZ) compared to healthy control subjects, with even lower activity in treatment resistant chronic SCZ patients, implicating NDEL1 activity in SCZ. Herein, higher NDEL1 activity was observed in the blood and several brain regions of a validated animal model for SCZ at baseline. In addition, long-term treatment with typical or atypical antipsychotics, under conditions in which SCZ-like phenotypes were reported to be reversed in this animal model for SCZ, showed a significant NDEL1 activity reduction in blood and brain regions which is in line with clinical data. Importantly, these results support measuring NDEL1 enzyme activity in the peripheral blood to predict changes in NDEL1 activity in the CNS. Also, acute administration of psychostimulants, at levels reported to induce SCZ-like phenotype in normal rat strains, increased NDEL1 enzyme activity in blood. Therefore, alterations in NDEL1 activity after treatment with antipsychotics or psychostimulants may suggest a possible modulation of NDEL1 activity secondary to neurotransmission homeostasis and provide new insights into the role of NDEL1 in SCZ pathophysiology. (AU)

FAPESP's process: 19/09207-3 - Study of molecular and cellular mechanisms in mental disorders
Grantee:João Victor Silva Nani
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/02413-1 - Validation of crotamine as a biomarker and evaluation of its potential use in the therapy of human diseases
Grantee:Mirian Akemi Furuie Hayashi
Support Opportunities: Regular Research Grants
FAPESP's process: 12/50191-4 - Synthesis, kinetic studies and applications of substrates and inhibitors for proteolytic enzymes
Grantee:Maria Aparecida Juliano
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/13392-4 - Evaluation of the use of analogs of crotamine for diagnosis or therapy
Grantee:Mirian Akemi Furuie Hayashi
Support Opportunities: Regular Research Grants