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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

he use of omega-3 fatty acids in the treatment of oral disease

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Azuma, Mariane Maffei [1] ; Morais Cardoso, Carolina de Barros [2] ; da Silva, Cristiane Cantiga [2] ; de Oliveira, Pedro Henrique Chaves [2] ; Jacinto, Rogerio de Castilho [2] ; Andrada, Ana Cristina [3] ; Cintra, Luciano Tavares Angelo [2, 4]
Total Authors: 7
[1] Univ Michigan, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 - USA
[2] Sao Paulo State Univ Unesp, Dept Prevent & Restorat Dent, Sch Dent, R Jose Bonifacio 1193, Aracatuba, SP - Brazil
[3] Univ Detroit, Mercy Sch Dent, Div Endodont, Detroit, MI 48221 - USA
[4] Sao Paulo State Univ UNESP, Sch Dent, Ctr Disabled Persons CAOE, Aracatuba - Brazil
Total Affiliations: 4
Document type: Review article
Source: ORAL DISEASES; v. 28, n. 2 OCT 2020.
Web of Science Citations: 0

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been reported to exert important roles in the inflammatory response. There are many inflammatory diseases in dentistry which support the administration of omega-3 PUFAs as an adjunct therapy during the treatment of these diseases. The aim of this review was to evaluate the use of omega-3 PUFAs as an adjuvant therapy during the treatment of buccal diseases. The review showed that supplementation with omega-3 PUFAs was used for treatment of gingivitis, periodontal diseases, apical periodontitis, stomatitis, and orthodontic tooth movement. The results indicate that omega-3 PUFAs decreased the number of pro-inflammatory mediators in the gingival tissues of individuals with gingivitis and periodontitis. In apical periodontitis, the supplementation suppressed bone resorption and promoted bone formation in the periapical area of rats. During orthodontic movement, the supplementation showed a decrease of bone resorption in rats. It also showed that painful symptoms of recurrent aphthous stomatitis were alleviated in supplemented patients. In conclusion, the omega-3 PUFAs may be used as an adjuvant therapy in the treatment of inflammatory diseases that affect the oral cavity. However, more studies are required to elucidate the role of omega-3 PUFAs in decreasing oral cavity inflammatory processes. (AU)

FAPESP's process: 13/26390-0 - Local and systemic influence of dietary supplementation with omega - 3 in rats with endodontic infection
Grantee:Mariane Maffei Azuma
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/03054-0 - The influence of dietary supplementation with ômega-3 fatty acids in the triglyceride levels and bone resorption in Wistar rats with endodontic infection
Grantee:Carolina de Barros Morais Cardoso
Support type: Scholarships in Brazil - Scientific Initiation