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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Concentrations of Acute-Phase Proteins in Milk from Cows with Clinical Mastitis Caused by Different Pathogens

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Dalanezi, Felipe M. [1] ; Schmidt, Elizabeth M. S. [2] ; Joaquim, Samea F. [1] ; Guimaraes, Felipe F. [1] ; Guerra, Simoni T. [1] ; Lopes, Bruna C. [1] ; Cerri, Ronaldo L. A. [3] ; Chadwick, Christopher [4] ; Langoni, Helio [1]
Total Authors: 9
[1] Sao Paulo State Univ UNESP, Dept Anim Prod & Prevent Vet Med, Fac Med Vet & Anim Sci, BR-18168681 Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Dept Vet Clin Sci, Fac Med Vet & Anim Sci, BR-18168681 Sao Paulo - Brazil
[3] Univ British Columbia, Fac Land & Food Syst, Appl Anim Biol, Vancouver, BC V6T 1Z4 - Canada
[4] Life Diag Inc, W Chester, PA 19380 - USA
Total Affiliations: 4
Document type: Journal article
Source: PATHOGENS; v. 9, n. 9 SEP 2020.
Web of Science Citations: 0

Among the new diagnostic methods for mastitis detection under development, milk acute-phase proteins (APPs) are receiving special attention. The study aimed to compare the profile of milk APPs from cows with natural clinical mastitis caused by distinct pathogens. The concentrations of haptoglobin (Hp), serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP), and C-reactive protein (CRP) were measured by Spatial Proximity Analyte Reagent Capture Luminescence (SPARCL). Each APP was compared across the pathogens causing mastitis. The APPs differed statistically (p< 0.05) among the pathogens causing udder infection. There were significant and positive correlations among the concentration profile, for each pathogen, in three of four APPs studied. It can be concluded that the pathogen causing mastitis could modify the profile of release of the APPs in milk. The profile of Hp, AGP, and CRP demonstrated significant correlation, indicating that the three APPs are suggested as biomarkers, in milk, for bovine mastitis. (AU)

FAPESP's process: 15/26055-1 - Influence of pathogens causing clinical mastitis in dairy cows reproductive indices
Grantee:Felipe Morales Dalanezi
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/19688-8 - E. coli, Klebsiella pnemoniae and Enterococcus spp: impact of virulence factors in bovine mastitis and public health concern
Grantee:Helio Langoni
Support type: Research Projects - Thematic Grants