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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Systemic Cytokine Profiles of CD4+T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD

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Author(s):
Uzeloto, Juliana Souza [1] ; de Toledo-Arruda, Alessandra Choqueta [2] ; de Alencar Silva, Bruna Spolador [1] ; Golim, Marjorie de Assis [3] ; Marques Braz, Aline Marcia [3] ; de Lima, Fabiano Francisco [1] ; Grigoletto, Isis [1] ; Cipulo Ramos, Ercy Mara [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ UNESP, Fac Sci & Technol, Dept Physiotherapy, Grad Program Physiotherapy, Presidente Prudente, SP - Brazil
[2] Univ Fed Rio de Janeiro, Dept Physiotherapy, Rio De Janeiro - Brazil
[3] Sao Paulo State Univ UNESP, Botucatu Med Sch, Postgrad Program Res & Dev Med Biotechnolog, Blood Ctr, Flow Cytometry Lab, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE; v. 15, p. 2931-2940, 2020.
Web of Science Citations: 0
Abstract

Aims: To evaluate the expressions of intracellular cytokines in CD4+ T lymphocytes and to investigate the correlation between biomarker expressions and clinical and functional characteristics of stable COPD patients. Patients and Methods: Peripheral blood was collected from 36 COPD patients, and the expression of cytokines (IL-8, IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-alpha) in T lymphocytes CD4 + was investigated. In addition, lung function, dyspnea symptoms, quality of life, vital signs, body composition, level of physical activity, peripheral muscle strength, and functional capacity were assessed. Results: Individuals with greater bronchial obstruction present a higher proportion of CD4 + IL-2 + lymphocytes compared to individuals with less severe bronchial obstruction. We found a positive correlation between the expression of the cytokines IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-alpha in CD4+ T lymphocytes. In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day. Conclusion: Systemic CD4+IL-2+, IL-8+, and IL-10+ T lymphocytes presented a correlation with clinical characteristics and functional status in stable COPD. (AU)

FAPESP's process: 17/10145-7 - Effects of the inclusion of a functional circuit to aerobic and resistance training on functionality, physical activity in daily life and immuno-metabolic response of patients with COPD: a randomized clinical trial with follow-up
Grantee:Ercy Mara Cipulo Ramos
Support type: Regular Research Grants
FAPESP's process: 18/04870-3 - INVESTIGATION OF THE EFFECT OF COMBINED PHYSICAL TRAINING ON THE INFLAMMATORY PROFILE AND FUNCTIONAL CAPACITY OF COPD PATIENTS: RANDOMIZED CLINICAL STUDY
Grantee:Juliana Souza Uzeloto
Support type: Scholarships in Brazil - Doctorate