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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anti-Flavivirus Vaccines: Review of the Present Situation and Perspectives of Subunit Vaccines Produced in Escherichia coli

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Araujo, Sergio C. [1] ; Pereira, Lennon R. [2] ; Alves, Rubens P. S. [2] ; Andreata-Santos, Robert [2] ; Kanno, Alex I. [1] ; Ferreira, Luis Carlos S. [2] ; Goncalves, Viviane M. [1]
Total Authors: 7
[1] Inst Butantan, Lab Vaccine Dev, BR-05503900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Lab Vaccine Dev, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: VACCINES; v. 8, n. 3 SEP 2020.
Web of Science Citations: 0

This article aims to review the present status of anti-flavivirus subunit vaccines, both those at the experimental stage and those already available for clinical use. Aspects regarding development of vaccines to Yellow Fever virus, (YFV), Dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) are highlighted, with particular emphasis on purified recombinant proteins generated in bacterial cells. Currently licensed anti-flavivirus vaccines are based on inactivated, attenuated, or virus-vector vaccines. However, technological advances in the generation of recombinant antigens with preserved structural and immunological determinants reveal new possibilities for the development of recombinant protein-based vaccine formulations for clinical testing. Furthermore, novel proposals for multi-epitope vaccines and the discovery of new adjuvants and delivery systems that enhance and/or modulate immune responses can pave the way for the development of successful subunit vaccines. Nonetheless, advances in this field require high investments that will probably not raise interest from private pharmaceutical companies and, therefore, will require support by international philanthropic organizations and governments of the countries more severely stricken by these viruses. (AU)

FAPESP's process: 18/24683-3 - Production of envelope protein domain III of Zika Virus in Escherichia coli: evaluation of the protein obtained from soluble fraction and inclusion bodies
Grantee:Sérgio Carneiro Araújo
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/20045-7 - Antigen discovery and development of serological diagnostic methods and vaccine approaches against the Zika Virus (ZIKV)
Grantee:Luis Carlos de Souza Ferreira
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/23560-0 - Development of uniplex and multiplex diagnostic platforms for arbovirus infection using recombinant proteins
Grantee:Robert Andreata Santos
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 19/18205-4 - Identification and characterization of peptides capable to interfere with the infection mechanisms of dengue and zika viruses.
Grantee:Lennon Ramos Pereira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/02352-7 - Vaccines for control of dengue: vaccine potential of the combination of the non-structural proteins in the generation of protective cell response in an experimental model
Grantee:Rubens Prince dos Santos Alves
Support type: Scholarships in Brazil - Doctorate