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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Natural Self-Ligand Gamma Delta T Cell Receptors (gamma delta TCRs) Insight: The Potential of Induced IgG

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de Sousa, Thamires Rodrigues [1] ; Victor, Jefferson Russo [1, 2]
Total Authors: 2
[1] Univ Sao Paulo, Med Sch, Div Clin Dermatol, Lab Med Invest LIM 56, BR-05403000 Sao Paulo - Brazil
[2] Laureate Int Univ, FMU, Div Environm Hlth, BR-04505002 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: VACCINES; v. 8, n. 3 SEP 2020.
Web of Science Citations: 0

A gamma delta T cell acquires functional properties in response to the gamma delta T cell receptor gamma delta TCR signal strength during its development in the thymus. The elucidation of the potential ligands of gamma delta T cell receptors are of extreme importance; however, they are still not understood. Here we revise the actual state of the art of candidates to exert the function of gamma delta TCR ligands, and propose a theoretical contribution about new potential ligands of gamma delta TCRs, based on biological and hypothetical pieces of evidence in the literature. In conclusion, we hypothetically suggest a possible role of induced antibodies according to the individual's immune status, mainly of the IgG subclass, acting as gamma delta TCR ligands. Considering that IgG production is involved in some essential immunotherapy protocols, and almost all vaccination protocols, our discussion opens a new and broad field to further exploration. (AU)

FAPESP's process: 19/09741-0 - Analysis of the modulating effect of IgG antibodies from atopic individuals to the mite Dermatophagoides pteronyssiunus on the maturation and cytokine production of human intrathymic lymphocytes
Grantee:Thamires Rodrigues de Sousa
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/05181-7 - Translational evaluation of IgG effect upon the maturation of offspring thymus derived TCD4, TCD8, nTreg, gammadeltaT and e B cells.
Grantee:Alberto José da Silva Duarte
Support type: Regular Research Grants