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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic

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Author(s):
Damiot, Anthony [1] ; Pinto, Ana Jessica [1] ; Turner, JamesE. [2] ; Gualano, Bruno [3, 1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Div Rheumatol, Appl Physiol & Nutr Res Grp, Fac Med FMUSP, Sao Paulo - Brazil
[2] Univ Bath, Dept Hlth, Bath, Avon - England
[3] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Gerontology; v. 66, n. 5, p. 431-438, SEP 2020.
Web of Science Citations: 3
Abstract

Social distancing has been adopted worldwide to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Social isolation is likely to lead to a decline in physical activity, which could result in immune system dysfunction, thereby increasing infection susceptibility and exacerbating the pathophysiology of conditions that are common among older adults, including cardiovascular disease, cancer, and inflammatory disorders. Older adults and people living with these comorbidities are at a greater risk for complications during coronavirus disease 2019 (COVID-19). In this review, we discuss the negative impact of physical inactivity on immune function and showcase evidence that regular physical activity may be an effective strategy to counter some of the deleterious effects of social isolation. Furthermore, we briefly highlight key research questions in exercise immunology, with a focus on older adults in the context of COVID-19. Although it is worth emphasizing that there is no direct evidence that physical activity can prevent or treat COVID-19, promoting an active lifestyle is a key intervention to counteract the effects of social isolation, especially in older adults and other at-risk individuals, such as those living with chronic diseases associated with ageing and lifestyle. (c) 2020 S. Karger AG, Basel (AU)

FAPESP's process: 18/19418-9 - Acute and chronic effects of reducing sedentary time in rheumatoid arthritis: the Take a stand for health study
Grantee:Ana Jéssica Pinto
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 19/22160-6 - Reducing sedentary time in bariatric patients: a proof-of-concept, laboratorial study
Grantee:Anthony Damiot
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/26937-4 - Studies on physical (in)activity in patients with rheumatoid arthritis: characterization, associations with disease and effects of breaking up sedentary time
Grantee:Ana Jéssica Pinto
Support type: Scholarships in Brazil - Doctorate (Direct)