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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship Between PET-Assessed Amyloid Burden and Visual and Verbal Episodic Memory Performance in Elderly Subjects

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Squarzoni, Paula [1, 2] ; Faria, Daniele de Paula [2, 3] ; Yassuda, Monica Sanches [4] ; de Gobbi Porto, Fabio Henrique [2, 3] ; Coutinho, Artur Martins [2, 3] ; da Costa, Naomi Antunes [1, 2] ; Nitrini, Ricardo [4] ; Forlenza, Orestes Vicente [5] ; de Souza Duran, Fabio Luiz [1, 2] ; Dozzi Brucki, Sonia Maria [4] ; Buchpiguel, Carlos Alberto [2, 3] ; Busatto, Geraldo F. [1, 2]
Total Authors: 12
[1] Univ Sao Paulo, Fac Med FMUSP, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Nucleo Apoio Pesquisa Neurociencia Aplicada NAPNA, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Lab Nucl Med LIM 43, Dept Radiol & Oncol, Fac Med FMUSP, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Fac Med FMUSP, Dept Neurol, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Dept Psychiat, Lab Neurosci LIM 27, Fac Med FMUSP, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 78, n. 1, p. 229-244, 2020.
Web of Science Citations: 0

Background: Studies of elderly subjects using biomarkers that are proxies for Alzheimer's disease (AD) pathology have the potential to document meaningful relationships between cognitive performance and biomarker changes along the AD continuum. Objective: To document cognitive performance differences across distinct AD stages using a categorization based on the presence of PET-assessed amyloid-beta (A beta) burden and neurodegeneration. Methods: Patients with mild dementia compatible with AD (n = 38) or amnestic mild cognitive impairment (aMCI; n = 43) and a cognitively unimpaired group (n = 27) underwent PET with Pittsburgh compound-B (PiB) assessing A beta aggregation (A+) and {[}F-18]FDG-PET assessing neurodegeneration ((N)+). Cognitive performance was assessed with verbal and visual episodic memory tests and the Mini-Mental State Examination. Results: The A+(N)+ subgroup (n = 32) showed decreased (p < 0.001) cognitive test scores compared to both A+(N)-(n = 18) and A-(N)- (n = 49) subjects, who presented highly similar mean cognitive scores. Despite its modest size (n = 9), the A-(N)+ subgroup showed lower (p < 0.043) verbal memory scores relative to A-(N)- subjects, and trend lower (p = 0.096) scores relative to A+(N)- subjects. Continuous A beta measures (standard uptake value ratios of PiB uptake) were correlated most significantly with visual memory scores both in the overall sample and when analyses were restricted to dementia or (N)+ subjects, but not in non-dementia or (N)- groups. Conclusion: These results demonstrate that significant A beta-cognition relationships are highly salient at disease stages involving neurodegeneration. The fact that findings relating A beta burden to memory performance were detected only at (N)+ stages, together with the similarity of test scores between A+(N)- and A-(N)- subjects, reinforce the view that A beta-cognition relationships during early AD stages may remain undetectable unless substantially large samples are evaluated. (AU)

FAPESP's process: 14/50873-3 - INCT 2014: National Institute of Biomarkers in Neuropsychiatry
Grantee:Wagner Farid Gattaz
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/50329-6 - Translational neuroscience of Alzheimer's disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers
Grantee:Geraldo Busatto Filho
Support type: Research Projects - Thematic Grants