Perspective: The Potential Effects of Naringenin in COVID-19

Author(s)

Alberca, Ricardo Wesley ^{[1, 2]} ; Teixeira, Franciane Mouradian Emidio ^[3] ; Beserra, Danielle Rosa ^{[1, 2]} ; de Oliveira, Emily Araujo ^{[1, 2]} ; Andrade, Milena Mary de Souza ^{[1, 2]} ; Pietrobon, Anna Julia ^[3] ; Sato, Maria Notomi ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: FRONTIERS IN IMMUNOLOGY; v. 11, SEP 25 2020.
• Web of Science Citations: 0

Abstract

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection. (AU)

• FAPESP's process: 19/02679-7 - Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice
• Grantee: Ricardo Wesley Alberca Custódio
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring
• Grantee: Maria Notomi Sato
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/18230-6 - Evaluation of the efficacy of the Zika Virus chimeric DNA vaccine and the lysosomal-associated membrane protein in mice
• Grantee: Franciane Mouradian Emidio Teixeira
• Support Opportunities: Scholarships in Brazil - Doctorate