| Full text | |
| Author(s): |
Rampini, Denise
[1]
;
Prieto, Diego Campos
[1]
;
Colzi, Ana Luisa
[1]
;
de Araujo, Renan Vinicius
[1]
;
Giarolla, Jeanine
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Av Prof Lineu Prestes 580, Cidade Univ, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | MINI-REVIEWS IN MEDICINAL CHEMISTRY; v. 20, n. 18, p. 1917-1928, 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide, being a rapidly spreading disease with possible severe complications for pregnant women and neonates. There is currently no preventative therapy or specific treatment available. Within this context, drug repositioning is a very promising approach for the discovery of new treatment compounds, since old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to identify promising compounds to combat this virus. The mechanism of action at the molecular level and the structure-activity relationship of prototypes are discussed. Among the candidates identified, we highlight sofosbuvir, chloroquine and suramin, which present a greater quantity of experimental data to draw on for our discussion. The current treatment is palliative; therefore, this study is of paramount importance in identifying drug candidates useful for combating ZIKV. (AU) | |
| FAPESP's process: | 17/21154-7 - First generation polyamidoamine (PAMAM): design and synthesis of a potentially active tuberculosis prodrug |
| Grantee: | Renan Vinicius de Araujo |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |