Future and Perspectives of the Zika Virus: Drug Re... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Future and Perspectives of the Zika Virus: Drug Repurposing as a Powerful Tool for Treatment Insights

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Author(s):
Rampini, Denise [1] ; Prieto, Diego Campos [1] ; Colzi, Ana Luisa [1] ; de Araujo, Renan Vinicius [1] ; Giarolla, Jeanine [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Av Prof Lineu Prestes 580, Cidade Univ, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: MINI-REVIEWS IN MEDICINAL CHEMISTRY; v. 20, n. 18, p. 1917-1928, 2020.
Web of Science Citations: 0
Abstract

The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide, being a rapidly spreading disease with possible severe complications for pregnant women and neonates. There is currently no preventative therapy or specific treatment available. Within this context, drug repositioning is a very promising approach for the discovery of new treatment compounds, since old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to identify promising compounds to combat this virus. The mechanism of action at the molecular level and the structure-activity relationship of prototypes are discussed. Among the candidates identified, we highlight sofosbuvir, chloroquine and suramin, which present a greater quantity of experimental data to draw on for our discussion. The current treatment is palliative; therefore, this study is of paramount importance in identifying drug candidates useful for combating ZIKV. (AU)

FAPESP's process: 17/21154-7 - First generation polyamidoamine (PAMAM): design and synthesis of a potentially active tuberculosis prodrug
Grantee:Renan Vinicius de Araujo
Support Opportunities: Scholarships in Brazil - Scientific Initiation