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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Microbiome and Cervical Cancer

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Castanheira, Cristina Paula [1] ; Sallas, Mayara Luciana [2] ; Nunes, Rafaella Almeida Lima [2] ; Lorenzi, Noely Paula Cristina [3] ; Termini, Lara [2]
Total Authors: 5
[1] Conjunto Hosp Mandaqui, Dept Obstet & Gynecol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Canc Estado Sao Paulo Octavio Frias Oliveira, Ctr Invest Translac Oncol, Innovat Canc Lab, Hosp Clin, Fac Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Hosp Univ, Dept Gynecol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: PATHOBIOLOGY; v. 88, n. 2 NOV 2020.
Web of Science Citations: 0

Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and progression either by favoring or by preventing HPV infection and persistence. The microbiome of a healthy female genital tract is characterized by the presence of 1 or few varieties of lactobacilli. However, high-throughput studies addressing the bacterial diversity and abundance in the female genital tract have shown that several factors, including hormonal levels, hygiene habits, and sexually transmitted diseases may disrupt the natural balance, favoring the outgrowth of some groups of bacteria, which in turn may favor some pathological states. Recently, the vaginal microbiome has emerged as a new variable that could greatly influence the natural history of HPV infections and their clinical impact. In this context, changes in the vaginal microbiome have been detected in women infected with HPV and women with HPV-associated lesions and cancer. However, the role of specific bacteria groups in the development/progression or prevention/regression of HPV-associated pathologies is not well understood. In this review we summarize the current knowledge concerning changes in vaginal microbiome and cervical disease. We discuss the potential functional interplay between specific bacterial groups and HPV infection outcomes. (AU)

Grantee:Lara Termini
Support type: Regular Research Grants