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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice

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Author(s):
Donado-Pestana, Carlos M. [1] ; Pessoa, Erika V. M. [1] ; Rodrigues, Larissa [1] ; Rossi, Rafaela [1] ; Moura, Marcio H. C. [1] ; dos Santos-Donado, Priscila R. [2] ; Castro, Erique [3] ; Festuccia, William T. [3] ; Genovese, Maria Ines [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Alimentos & Nutr Expt, Av Prof Lineu Prestes 580, Bloco 14, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz ESALQ, Dept Agroind Alimentos & Nutr, Piracicaba, SP - Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Food Chemistry; v. 340, MAR 15 2021.
Web of Science Citations: 0
Abstract

Polyphenols from cambuci (CBC) (Campomanesia phaea (O. Berg.)), a Brazilian native fruit, were investigated on therapeutic actions mitigating insulin resistance and hepatic steatosis in high-fat-sucrose diet (HFS) induced obese mice. For this, C57BL/6J mice fed with a obesogenic and diabetogenic HFS diet were administered with either water or two CBC doses (36 or 74 mg gallic acid equivalent (GAE)/kg body weight) by gavage from week 6 to week 14 (end-point) of HFS feeding. CBC reduced body weight gain, inflammation, hepatic steatosis, hyperglycemia, glucose intolerance, and insulin resistance in liver and skeletal muscle of obese mice, and such effects were associated with activation of Akt and AMPK in these tissues. In conclusion, polyphenols from CBC show important therapeutic actions ameliorating obesity-associated complications. (AU)

FAPESP's process: 15/19530-5 - Involvement of the nutrient sensor mTOR in the development of obesity associated chronic metabolic diseases
Grantee:William Tadeu Lara Festuccia
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/24477-4 - Modulation of intestinal microbiota and tissue proteomic analyses in obesity-induced inflammation and insulin resistance: Role of polyphenols from Brazilian native Myrtaceae fruits
Grantee:Maria Ines Genovese Rodriguez
Support Opportunities: Regular Research Grants