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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

TAM and TIM receptors mRNA expression in Zika virus infected placentas

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Nobrega, Guilherme M. [1, 2] ; Samogim, Ana Paula [2] ; Parise, Pierina L. [2] ; Venceslau, Emanuella M. [1] ; Guida, Jose Paulo S. [1] ; Japecanga, Rodolfo R. [1] ; Amorim, Mariene R. [2] ; Toledo-Teixeira, Daniel A. [2] ; Forato, Julia [2] ; Consonni, Silvio R. [3] ; Costa, Maria Laura [1] ; Proenca-Modena, Jose Luiz [2, 4] ; Network, Zika-Unicamp
Total Authors: 13
[1] Univ Campinas UNICAMP, Sch Med Sci, Dept Obstet & Gynecol, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Campinas, SP - Brazil
[3] Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[4] Univ Campinas UNICAMP, Expt Med Res Cluster EMRC, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Placenta; v. 101, p. 204-207, NOV 2020.
Web of Science Citations: 0

To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy. (AU)

FAPESP's process: 17/26908-0 - The role of IRF-5 in Oropouche virus pathogenesis and neurovirulence
Grantee:Pierina Lorencini Parise
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/22062-9 - Arbovirus detection and characterization in Campinas
Grantee:Julia Forato
Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 17/02402-0 - The role of adaptive immune response in neuroinvasion by Oropouche and Zika virus
Grantee:Daniel Augusto de Toledo Teixeira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 19/18720-6 - Characterization of placental Virome and immune transcriptome of pregnant women with Zika Virus infection and high-risk pregnancies
Grantee:Guilherme de Moraes Nobrega
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
Grantee:José Luiz Proença Módena
Support Opportunities: Research Grants - Young Investigators Grants