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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effect of carnosine or beta-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis

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Author(s):
Matthews, Joseph J. [1, 2] ; Dolan, Eimear [3] ; Swinton, Paul A. [4] ; Santos, Livia [2] ; Artioli, Guilherme G. [3] ; Turner, Mark D. [5] ; Elliott-Sale, Kirsty J. [2] ; Sale, Craig [2]
Total Authors: 8
Affiliation:
[1] Birmingham City Univ, Dept Sport & Exercise, Sch Hlth & Life Sci, Res Ctr Life & Sport Sci CLaSS, Birmingham, W Midlands - England
[2] Nottingham Trent Univ, Sch Sci & Technol, Musculoskeletal Physiol Res Grp, Sport Hlth & Performance Enhancement SHAPE Res Ct, Nottingham - England
[3] Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Appl Physiol & Nutr Res Grp, Sao Paulo - Brazil
[4] Robert Gordon Univ, Sch Hlth Sci, Aberdeen - Scotland
[5] Nottingham Trent Univ, Sch Sci & Technol, Ctr Diabet Chron Dis & Ageing, Nottingham - England
Total Affiliations: 5
Document type: Review article
Source: SYSTEMATIC REVIEWS; v. 9, n. 1 DEC 5 2020.
Web of Science Citations: 0
Abstract

Background Diabetes is a major public health issue and there is a need to develop low-cost, novel interventions to prevent or reduce disease progression. Growing evidence shows that supplementation with carnosine, or its rate-limiting precursor beta-alanine, can ameliorate aspects of the metabolic dysregulation that occurs in diabetes. There is, however, a need to develop a better understanding of the magnitude of effect and the factors associated with positive outcomes. The purpose of this systematic review and meta-analysis is to evaluate the effect of carnosine or beta-alanine supplementation on markers of glycaemic control and insulin resistance in humans and animals. Methods We will perform a systematic search for randomised and non-randomised controlled trials. Studies will be retrieved by searching electronic databases, clinical trial registers, author review, and cross-referencing. Primary outcomes include changes in (i) fasting glucose, (ii) glycated haemoglobin, and (iii) 2-h glucose following a glucose tolerance test. A set of additional outcomes includes other markers of glycaemic control and insulin resistance. Risk of bias (RoB) will be assessed using the Cochrane RoB 2.0 tool (human studies) and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) RoB tool (animal studies). Confidence in the cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. All meta-analyses will be conducted within a Bayesian framework, providing a flexible modelling approach to account for uncertainty in model parameters and underlying structures within the data. Discussion By including all available human and animal data, we will provide the most comprehensive overview on the topic to date. The results will have implications for those working in prediabetes, diabetes, and metabolic health in general and may lead to the development of new treatment approaches. Dissemination Study results will be presented at a professional conference and published in a peer-reviewed journal. Systematic review registration (AU)

FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 19/26899-6 - The bone response to exercise a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 19/25032-9 - The role of carnosine on Ca2+ handling, control of oxidative stress and protection against protein glycation: advances and applications of the study "Life Without Carnosine"
Grantee:Guilherme Giannini Artioli
Support type: Regular Research Grants
FAPESP's process: 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support type: Research Grants - Young Investigators Grants