| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Barao Maua Univ Ctr, 423 Ramos Azevedo St, BR-14090180 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
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| Document type: | Journal article |
| Source: | Carbohydrate Research; v. 498, DEC 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
The synthesis of MUC1 glycopeptides bearing modified tumor-associated carbohydrate antigens (TACAs) represents an effective strategy to develop potential antitumor vaccines that trigger strong immune response. In this context, we present herein the multistep synthesis of the triazole glycosyl amino acid Neu5Ac-alpha/82-triazole-68GalNAc-ThrOH 1 as STn antigen analog, along with its assembly on the corresponding MUC1 peptide to give NAcProAsp {[}Neu5Ac alpha/82-triazole-6-8GalNAc]ThrArgProGlyOH 2. Despite interacting differently with SM3 monoclonal antibody, as shown by molecular dynamic simulations, this unnatural triazole glycopeptide may represent a promising candidate for cancer immunotherapy. (AU) | |
| FAPESP's process: | 12/19390-0 - Development of mucin glycoconjugates with diagnostic and therapeutic applications in muscular dystrophies and cancer |
| Grantee: | Vanessa Leiria Campo |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/04699-7 - Synthesis of mucin glycopeptide containing tumor antigen analogue with potential therapeutic applications in cancer |
| Grantee: | Marcelo Fiori Marchiori |
| Support Opportunities: | Scholarships in Brazil - Master |