Comparative study of anaesthesia induction in obese dogs using propofol dosages based on lean body weight or total body weight

Author(s)

Devito, Fernanda Correa ^[1] ; Fonseca Patricio, Geni Cristina ^[1] ; Flor, Patricia Bonifacio ^[1] ; Annibale Vendramini, Thiago Henrique ^[1] ; Amaral, Andressa Rodrigues ^[1] ; Pfrimer, Karina ^[2] ; Brunetto, Marcio Antonio ^[1] ; Gaido Cortopassi, Silvia Renata ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med Vet & Zootecnia FMVZ, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto FMRP, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: VETERINARY AND ANIMAL SCIENCE; v. 10, DEC 2020.
• Web of Science Citations: 0

Abstract

The objective of this study was to compare the dosages for anesthesia induction in obese dogs using propofol based on lean body weight or total body weight. For this purpose, seven dogs with ideal body condition score (BCS) (BCS 4-5; 17.3 +/- 2.5% fat mass) were included in the control group (CG), seven obese dogs (BCS 8-9; 45.7 +/- 2.9% fat mass) in the total body weight group (TBWG) and seven obese dogs (BCS 8-9; 42.8 +/- 6.3% fat mass) in the lean body weight group (LBWG). Anaesthesia was induced by a constant rate infusion of propofol at 150 mg kg(-1) hour(-1) through a propofol infusion pump until the loss of consciousness; the animals in CG and TBWG received a propofol infusion based on total body weight; the animals in LBWG received a propofol infusion based on lean body mass (in kg) determined by the deuterium dilution method. The results were compared between the groups using the Tukey test (p < 0.05). The propofol dosage used was 11.4 +/- 3.2 mg kg(-1), 8.0 +/- 2.0 mg kg(-1) and 14.1 +/- 4.7 mg kg(-1) in groups CG, TBWG and LBWG, respectively, and they were different among all groups (p < 0.001). There was also a statistical difference in the time between the start of propofol infusion and loss of consciousness in which LBWG took longer than CG and TBWG (p = 0.004). This study shows that obese dogs require lower dosages of propofol when inducing anesthesia than ideal BCS dogs anesthetized with dosages based on total body weight, when the propofol dosages are calculated on the basis of muscle mass it should be increased. (AU)

• FAPESP's process: 13/15643-4 - Comparative study of propofol doses in the anesthesia induction of the obese dog
• Grantee: Fernanda Correa Devito
• Support Opportunities: Scholarships in Brazil - Master