| Full text | |
| Author(s): |
Fontes, Milene Tavares
[1]
;
Paula, Suliana Mesquita
[1]
;
Lino, Caroline Antunes
[2]
;
Senger, Nathalia
[2]
;
Couto, Gisele Kruger
[1]
;
de Morais Barreto-Chaves, Maria Luiza
[2]
;
Mill, Jose Geraldo
[3]
;
Rossoni, Luciana Venturini
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
[3] Fed Univ Espirito Santo UFES, Dept Physiol Sci, Vitoria, ES - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Clinical Science; v. 134, n. 23, p. 3195-3211, DEC 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
Perivascular adipose tissue (PVAT) dysfunction is associated with vascular damage in cardiometabolic diseases. Although heart failure (HF)-induced endothelial dysfunction is associated with renin-angiotensin system (RAS) activation, no data have correlated this syndrome with PVAT dysfunction. Thus, the aim of the present study was to investigate whether the hyperactivation of the RAS in PVAT participates in the vascular dysfunction observed in rats with HF after myocardial infarction surgery. Wire myograph studies were carried out in thoracic aorta rings in the presence and absence of PVAT. An anticontractile effect of PVAT was observed in the rings of the control rats in the presence (33%) or absence (11%) of endothelium. Moreover, this response was substantially reduced in animals with HF (5%), and acute type 1 angiotensin II receptor (AT1R) and type 2 angiotensin II receptor (AT2R) blockade restored the anticontractile effect of PVAT. In addition, the angiotensin-converting enzyme 1 (ACE1) activity (26%) and angiotensin II levels (51%), as well as the AT1R and AT2R gene expression, were enhanced in the PVAT of rats with HF. Associated with these al- terations, HF-induced lower nitric oxide bioavailability, oxidative stress and whitening of the C) PVAT, which suggests changes in the secretory function of this tissue. The ACE1/angiotensin II/AT1R and AT2R axes are involved in thoracic aorta PVAT dysfunction in rats with HF. These results suggest PVAT as a target in the pathophysiology of vascular dysfunction in HF and provide new perspectives for the treatment of this syndrome. (AU) | |
| FAPESP's process: | 14/20303-0 - Evaluation of the influence of perivascular adipose tissue (PVAT) on vascular reactivity of the aorta of infarcted rats submitted to aerobic and resistance training |
| Grantee: | Milene Tavares Fontes |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 16/08907-3 - The influence of perivascular adipose tissue on vascular reactivity of myocardial infarction rats submitted to combined training |
| Grantee: | Luciana Venturini Rossoni |
| Support Opportunities: | Regular Research Grants |