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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hepatotoxic and neuroendocrine effects in physicians occupationally exposed to most modern halogenated anesthetics and nitrous oxide

Full text
Author(s):
Aun, Aline G. [1] ; Souza, Katina M. [1] ; Guedes, Julia L. [1] ; Figueiredo, Drielle B. S. [1] ; Lara, Juliana R. [1] ; Silva, Mariane A. P. [1] ; Braz, Leandro G. [1] ; Braz, Mariana G. [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ Unesp, Med Sch, Dept Anesthesiol, Botucatu, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 81, JAN 2021.
Web of Science Citations: 0
Abstract

The lack of data on hepatic and hormonal markers for occupational exposure to most modern halogenated anesthetics has stimulated our research, which assessed liver enzymes, high-sensitivity C-reactive protein (hs-CRP) and neuroendocrine response. The study investigated 106 physicians who were categorized in an exposed group (primarily exposed to isoflurane and sevoflurane and less to desflurane and nitrous oxide) as well as as a control group. Anesthetic air monitoring was performed, and biological samples were analyzed for the most important liver enzymes, hs-CRP, adrenocorticotrophic hormone, cortisol and prolactin. No biomarkers were significantly different between the groups. Exposed males showed significant increases in cortisol and prolactin compared to unexposed males. However, values were within the reference ranges, and 22 % of exposed males versus 5 % of unexposed males exhibited higher prolactin values above the reference range. This study suggests that occupational exposure to the most commonly used inhalational anesthetics is not associated with hepatotoxicity or neurohormonal changes. (AU)

FAPESP's process: 16/15559-1 - Evaluation of redox status, inflammatory response, telomeres and gene expression in anesthesiologists
Grantee:Mariana Gobbo Braz
Support Opportunities: Regular Research Grants
FAPESP's process: 16/23902-8 - Evaluation of redox status, inflammatory response, telomeres and gene expression in anesthesiologists
Grantee:Kátina Meneghetti de Souza
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/20143-4 - Genotoxic, cytotoxic, oxidative and neuro-immune-endocrine monitoring in professionals exposed to waste anesthetic gases during medical residency
Grantee:Leandro Gobbo Braz
Support Opportunities: Regular Research Grants
FAPESP's process: 17/21504-8 - Evaluation of hematological, biochemical and antioxidant parameters in physicians exposed to waste of anesthetic gases during their medical residency
Grantee:Júlia Lisbôa Guedes
Support Opportunities: Scholarships in Brazil - Scientific Initiation