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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acute physical exercise increases PI3K-p110 alpha protein content in the hypothalamus of obese mice

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Author(s):
Gaspar, Rafael C. [1] ; Nakandakari, Susana C. B. R. [2] ; Munoz, Vitor R. [1] ; Vieira, Renan F. L. [1] ; da Silva, Adelino S. R. [3] ; Cintra, Dennys E. [4, 2] ; de Moura, Leandro P. [1, 4, 5] ; Ropelle, Eduardo R. [1, 4, 5] ; Pauli, Jose Rodrigo [1, 4, 5]
Total Authors: 9
Affiliation:
[1] Univ Campinas UNICAMP, Lab Mol Biol Exercise, Limeira - Brazil
[2] Univ Campinas UNICAMP, Lab Nutr Gen, Limeira - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto - Brazil
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Lab Cell Signaling, Campinas - Brazil
[5] Univ Campinas UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Limeira - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Anatomy; v. 238, n. 3, p. 743-750, MAR 2021.
Web of Science Citations: 0
Abstract

The anatomy of the hypothalamus includes many nuclei and a complex network of neurocircuits. In this context, some hypothalamic nuclei reside closer to the blood-brain barrier, allowing communication with the peripheral organs through some molecules, such as leptin. Leptin is considered the main adipokine for energy homeostasis control. Furthermore, leptin signalling in the hypothalamus can communicate with insulin signalling through the activation of phosphoinositide 3-kinase (PI3k). Previous data suggest that isoforms of PI3k are necessary to mediate insulin action in the hypothalamus. However, obese animals show impairment in the central signalling of these hormones. Thus, in the current study, we evaluated the role of acute exercise in the leptin and insulin pathways in the hypothalamus, as well as in food intake control in obese mice. Although acute physical exercise was not able to modulate leptin signalling, this protocol suppressed the increase in the suppressor of cytokine signalling 3 (SOCS3) protein levels. In addition, acute exercise increased the content of PI3k-p110 alpha protein in the hypothalamus. The exercised animals showed a strong tendency to reduction in cumulative food intake. For the first time, our results indicate physical exercise can increase PI3k-p110 alpha protein content in the hypothalamus of obese mice and regulate food intake. (AU)

FAPESP's process: 17/20542-3 - Role of physical exercise in regulation of Notch1 protein in obese mice: effects on hepatic lipogenesis and gluconeogenesis
Grantee:Rafael Calais Gaspar
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/07568-6 - The role of physical exercise on Rock protein pathway, and lipogenic regulation and gluconeogenesis in the liver of aged rats.
Grantee:Vitor Rosetto Muñoz
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/20872-6 - Effects of physical exercise on Rock protein signaling pathway, and lipogenic regulation and gluconeogenesis in the liver of aged rats
Grantee:José Rodrigo Pauli
Support Opportunities: Regular Research Grants