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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of phospho-tyrosine signaling in platelet biology and hemostasis

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Author(s):
Faria, Alessandra V. S. [1, 2] ; Andrade, Sheila S. [3] ; Peppelenbosch, Maikel P. [1] ; Ferreira-Halder, V, Carmen ; Fuhler, Gwenny M. [1]
Total Authors: 5
Affiliation:
[1] Erasmus MC, Dept Gastroenterol & Hepatol, NL-3000 CA Rotterdam - Netherlands
[2] V, Univ Estadual Campinas, Dept Biochem & Tissue Biol, UNICAMP, BR-13083862 Campinas, SP - Brazil
[3] PlateInnove Biotechnol, BR-13414018 Piracicaba, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH; v. 1868, n. 3 MAR 2021.
Web of Science Citations: 0
Abstract

Platelets are small enucleated cell fragments specialized in the control of hemostasis, but also playing a role in angiogenesis, inflammation and immunity. This plasticity demands a broad range of physiological processes. Platelet functions are mediated through a variety of receptors, the concerted action of which must be tightly regulated, in order to allow specific and timely responses to different stimuli. Protein phosphorylation is one of the main key regulatory mechanisms by which extracellular signals are conveyed. Despite the importance of platelets in health and disease, the molecular pathways underlying the activation of these cells are still under investigation. Here, we review current literature on signaling platelet biology and in particular emphasize the newly emerging role of phosphatases in these processes. (AU)

FAPESP's process: 15/20412-7 - Low molecular weight protein tyrosine phosphatase in colorectal cancer: from the bench to product generation
Grantee:Carmen Veríssima Ferreira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/26317-1 - InGrowth, biomimetic product developed by platelet bioactivation platform: applications in the veterinary and research and development areas
Grantee:Sheila Siqueira Andrade
Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
FAPESP's process: 17/08119-8 - Hematogenous tumor metastasis in colon rectal cancer cells: influence of LMWPTP and 3-bromopyruvate
Grantee:Alessandra Valéria de Sousa Faria
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/14459-3 - Human platelet lysate: from discard to value products in cell therapy and advanced cell-based medicine
Grantee:Sheila Siqueira Andrade
Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
FAPESP's process: 18/00736-0 - MicroRNAs in stool and platelets biology from gastroenterology cancer patient samples that correlate with ACP1 protein tyrosine phosphatase: colorectal cancer screening
Grantee:Alessandra Valéria de Sousa Faria
Support Opportunities: Scholarships abroad - Research Internship - Doctorate