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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of nanoparticulated chitosan on the biomodification of eroded dentin: clinical and photographic longitudinal analysis of restorations

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de Souza, Jose Caetano [1] ; Tedesco, Antonio Claudio [2] ; Unten Takahashi, Luandra Aparecida [2] ; Curylofo-Zotti, Fabiana Almeida [1] ; Souza-Gabriel, Aline Evangelista [1] ; Milori Corona, Silmara Aparecida [1]
Total Authors: 6
[1] Univ Sao Paulo, Ribeirao Preto Sch Dent, Dept Restorat Dent, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Ctr Nanotechnol & Tissue Engn, Photobiol & Photomed Res Grp, Dept Chem, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 1

To evaluate the influence of the pre-treatment with 2.5% nanoparticulate chitosan (2.5% NanoChi) solution on eroded dentin before the restorative dental treatment. The sample consisted of 22 patients (age between 33 and 52 years) with shallow or medium erosion lesions located in two homologous teeth. The teeth were randomly assigned according to dentin treatment: with 2.5% NanoChi and without with chitosan (control). The NanoChi were applied immediately after acid etching. The teeth were restored with Single Bond Universal (3M) and Charisma resin (Kulzer). Analyzes were done using modified USPHS (retention, secondary caries, marginal adaptation, and sensitivity) and photographic (color, marginal pigmentation, and anatomical form) criteria at 7 days (baseline) and 1 year. Population demographics, Kaplan-Meier estimates and log-rank test (Mantel-Cox) were calculated for 1 year (alpha =0.05). No significant difference was found in the survival rates between groups (p>0.05) at 7 days and 1 year after treatment. After 7 days, 100% of the restorations were scored as Alpha on all criteria. After 1 year, 91% of the NanoChi restorations were scored as Alpha and 9% as Charlie for the retention, marginal adaptation, and anatomical form criteria, while 86% of the control restorations (without NanoChi) received the Alpha score and 14% received the Charlie. Secondary caries, sensitivity, color, and marginal pigmentation criteria were scored as Alpha in 100% of the restorations. The biomodification of eroded dentin with 2.5% NanoChi did not influence the survival of the restorations after 1 year. The application of 2.5% NanoChi on eroded dentin did not increase failures of resin restorations after 1 year and it can be used as a pre-treatment solution. (AU)

FAPESP's process: 17/11582-1 - Dentin biomodification with phosphorylated chitosan nanoparticles (NanoPC) after selective removal of caries lesion by Er: YAG laser: Evaluation of antimicrobial and physicochemical properties
Grantee:Fabiana Almeida Curylofo Zotti
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/25757-8 - Influence of chitosan on the biomodification of eroded dentin: clinical and photographic longitudinal analysis of restorations
Grantee:José Caetano de Souza
Support type: Scholarships in Brazil - Scientific Initiation