Therapeutic Potential of Photobiomodulation In Alzheimer's Disease: A Systematic Review

Author(s)

Cardoso, Fabrizio dos Santos ^[1] ; Brandao Lopes Martins, Rodrigo Alvaro ^[2] ; da Silva, Sergio Gomes ^{[1, 3, 4]}

Affiliation

^[1] Univ Mogi das Cruzes UMC, Mogi Das Cruzes, SP - Brazil

^[2] Univ Vale Paraiba UNIVAP, Sao Jose Dos Campos, SP - Brazil

^[3] Ctr Univ UNIFAMINAS, Belo Horizonte, MG - Brazil

^[4] Hosp Canc Muriae, Fundacao Cristiano Varella, Muriae, MG - Brazil

• Document type: Review article
• Source: JOURNAL OF LASERS IN MEDICAL SCIENCES; v. 11, n. 4, 1, p. S16-S22, FAL 2020.
• Web of Science Citations: 0

Abstract

Introduction: Alzheimer disease (AD) is characterized by the decline of cognitive functions such as learning and memory. Scientific society has proposed some non-pharmacological interventions, among which photobiomodulation has gained prominence for its beneficial effects. Therefore, we investigated, through systematic review, the therapeutic potential of photobiomodulation in AD. Methods: This systematic review was registered under the number CRD42019128416 in the International Prospective Record of Systematic Reviews (PROSPERO). A systematic search was conducted on the bibliographic databases (PubMed and ScienceDirect) with the keywords based on MeSH terms: ``photobiomodulation therapy{''} or ``low-level laser therapy{''} or ``LLLT{''} or ``light emitting diode{''} and ``amyloid{''} or ``Alzheimer{''}. The data search was conducted from 2008 to 2019. We follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The search strategy included experimental in vivo and in vitro studies in the English language and photobiomodulation as a non-pharmacological intervention. We included 10 studies, being 5 in vivo studies, 4 in vitro studies and 1 study using in vivo and in vitro. To evaluate the quality of the studies, we used the Rob tool of the Systematic Review Center for Laboratory Animal Experimentation (SYRLE). Results: The studies showed that photobiomodulation is able to reduce inflammatory response, oxidative stress and apoptotic effects generated by amyloid beta (A beta) and restore mitochondrial function and cognitive behavior. Conclusion: Taken together, these results indicate that photobiomodulation may be a useful tool for treating AD. (AU)

• FAPESP's process: 17/16443-0 - Therapeutic potential of low-level laser in the brain of aged rats
• Grantee: Fabrízio dos Santos Cardoso
• Support type: Scholarships in Brazil - Doctorate