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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Increased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition

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Author(s):
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Portela, Luiz M. F. [1] ; Santos, Sergio A. A. [1] ; Constantino, Flavia B. [1] ; Camargo, Ana C. L. [1] ; Colombelli, Ketlin T. [1] ; Fioretto, Matheus N. [1] ; Barquilha, Caroline N. [1] ; Perico, Larissa L. [2, 1] ; Hiruma-Lima, Clelia A. [1] ; Scarano, Wellerson R. [1] ; Zambrano, Elena [3] ; Justulin, Luis A. [1]
Total Authors: 12
Affiliation:
[1] Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP - Brazil
[2] Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Calgary, AB - Canada
[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Mexico City, DF - Mexico
Total Affiliations: 3
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 523, MAR 1 2021.
Web of Science Citations: 0
Abstract

The concept of Developmental Origins of Health and Disease (DOHaD) states that exposure to malnutrition early in life increase the incidence of non-communicable chronic diseases throughout the lifespan. In this study, a reduction in serum testosterone and an increase in estrogen levels were shown in older rats born to protein malnourished dams (6% protein in the diet) during gestation and lactation. Intraprostatic levels of reduced glutathione were decreased, while tissue expression of glutathione S-transferase pi and sulfiredoxin-1 were increased in these animals. Strong immunostaining for alfametilacil CoA racemase (AMACR), vascular endothelial growth factor-A (VEGF-A), and aquaporin-1 (AQP1) was also observed. In silica analysis confirmed commonly deregulated proteins in the ventral prostate of old rats and patients with prostate cancer. In conclusion, the increase in oxidative stress associated with an imbalance of sex hormones may contribute to prostate carcinogenesis in offspring, highlighting early-life malnutrition as a key risk factor for this malignance. (AU)

FAPESP's process: 17/01063-7 - Integrative global analyzes of the rat ventral prostate submitted to maternal protein restriction and its repercussions with aging
Grantee:Luis Antonio Justulin Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 16/08789-0 - Aging of offspring rats submitted to parinatal protein restriction: evaluation of the metabolic status and the insulin / IGF signaling pathway in the ventral prostate at 540 days of age
Grantee:Luiz Marcos Frediani Portela
Support Opportunities: Scholarships in Brazil - Scientific Initiation