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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Are the 50's, the transition decade, in choroid plexus aging?

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Author(s):
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Tahira, Ana [1] ; Marques, Fernanda [2, 3] ; Lisboa, Bianca [1] ; Feltrin, Arthur [4, 1] ; Barbosa, Andre [5, 1] ; de Oliveira, Katia Cristina [4, 1] ; de Braganca Pereira, Carlos Alberto [6] ; Leite, Renata [7] ; Grinberg, Lea [7] ; Suemoto, Claudia [7] ; de Lucena Ferretti-Rebustini, Renata Eloah [7] ; Pasqualucci, Carlos Augusto [7] ; Jacob-Filho, Wilson [7] ; Brentani, Helena [8, 1] ; Palha, Joana Almeida [2, 3, 9]
Total Authors: 15
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Psiquiatria, LIM23, Sao Paulo, SP - Brazil
[2] ICVS 3Bs PT Govt Associate Lab, Braga - Portugal
[3] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga - Portugal
[4] Fed Univ ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
[5] Univ Sao Paulo, Interinst Grad Program Bioinformat, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Inst Matemat, Dept Estatistisca, Nucleo Bioinformat, Sao Paulo, SP - Brazil
[7] Univ Sao Paulo, Fac Med, Biobank Aging Studies Grp, Sao Paulo, SP - Brazil
[8] Univ Sao Paulo, Fac Med, Dept Psiquiatria, Sao Paulo, SP - Brazil
[9] Clin Acad Ctr, Braga - Portugal
Total Affiliations: 9
Document type: Journal article
Source: GEROSCIENCE; v. 43, n. 1, SI FEB 2021.
Web of Science Citations: 0
Abstract

The choroid plexus (CP) is an important structure for the brain. Besides its major role in the production of cerebrospinal fluid (CSF), it conveys signals originating from the brain, and from the circulatory system, shaping brain function in health and in pathology. Previous studies in rodents have revealed altered transcriptome both during aging and in various diseases of the central nervous system, including Alzheimer's disease. In the present study, a high-throughput sequencing of the CP transcriptome was performed in postmortem samples of clinically healthy individuals aged 50's through 80's. The data shows an age-related profile, with the main changes occurring in the transition from the 50's to the 60's, stabilizing thereafter. Specifically, neuronal and membrane functions distinguish the transcriptome between the 50's and the 60's, while neuronal and axon development and extracellular structure organization differentiate the 50's from the 70's. These findings suggest that changes in the CP transcriptome occur early in the aging process. Future studies will unravel whether these relate with processes occurring in late- onset brain diseases. (AU)

FAPESP's process: 14/10488-3 - Comparison of methods for prioritization of genes associated to neurodevelopment disorders
Grantee:Arthur Sant'Anna Feltrin
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/00591-1 - Studies of co-expression gene networks of the orbitofrontal cortex and striatum (postmortem study) of patients with OCD and controls
Grantee:Bianca Cristina Garcia Lisboa
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/00041-1 - Co-expression study among Y chromosome genes and autosomal genes and its relation to Autism Spectrum Disorders (ASD)
Grantee:Ana Carolina Tahira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/14658-2 - Copy number variation in genome of patients with obsessive-compulsive disorder and autism spectrum disorder with restricted interests and repetitive behaviors
Grantee:Helena Paula Brentani
Support type: Regular Research Grants