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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples

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Author(s):
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Pascoal, Livia Bitencourt [1, 2] ; Rodrigues, Patricia Brito [1] ; Genaro, Livia Moreira [2] ; dos Santos Pereira Gomes, Arilson Bernardo [1] ; Toledo-Teixeira, Daniel Augusto [3] ; Parise, Pierina Lorencini [3] ; Bispo-Dos-Santos, Karina [3] ; Simeoni, Camila Lopes [3] ; Guimaraes, Paula Veri [2] ; Buscaratti, Lucas Ildefonso [4] ; De Angeli Elston, Joao Gabriel [4] ; Marques-Souza, Henrique [4] ; Martins-de-Souza, Daniel [5, 6] ; Setsuko Ayrizono, Maria De Lourdes [2] ; Velloso, Licio Augusto [7, 8] ; Proenca-Modena, Jose Luiz [6, 3] ; Mendes Moraes-Vieira, Pedro Manoel [6, 9] ; Silva Mori, Marcelo Alves [6, 10] ; Farias, Alessandro Santos [6, 11] ; Ramirez Vinolo, Marco Aurelio [1, 6] ; Leal, Raquel Franco [2, 7]
Total Authors: 21
Affiliation:
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[1] Univ Estadual Campinas, UNICAMP, Dept Genet Microbiol & Immunol, Lab Immunoinflammat, Inst Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Surg, Inflammatory Bowel Dis Res Lab, Colorectal Surg Un, Campinas, SP - Brazil
[3] Univ Estadual Campinas, UNICAMP, Dept Genet Microbiol & Immunol, Lab Emerging Viruses, Inst Biol, Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Dept Biochem & Tissue Biol, Brazilian Lab Silencing Technol Blast, Inst Biol, Campinas - Brazil
[5] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, UNICAMP, Campinas, SP - Brazil
[6] Univ Estadual Campinas, UNICAMP, Expt Med Res Cluster EMRC, Campinas - Brazil
[7] Univ Estadual Campinas, UNICAMP, Obes & Comorbid Res Ctr OCRC, Campinas - Brazil
[8] Univ Estadual Campinas, Sch Med Sci, Lab Cell Signaling, UNICAMP, Campinas, SP - Brazil
[9] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Lab Immunometab, UNICAMP, Campinas, SP - Brazil
[10] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Aging Biol, UNICAMP, Campinas, SP - Brazil
[11] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Autoimmune Res Lab, UNICAMP, Campinas, SP - Brazil
Total Affiliations: 11
Document type: Journal article
Source: GUT MICROBES; v. 13, n. 1, p. 1-9, JAN 1 2021.
Web of Science Citations: 0
Abstract

Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells' permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine. (AU)

FAPESP's process: 20/04558-0 - Characterization of intrinsic risk factors and the development of new diagnostic and treatment alternatives for COVID-19
Grantee:José Luiz Proença Módena
Support type: Regular Research Grants
FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 19/06372-3 - Multiparametric flow cytometry
Grantee:Alessandro dos Santos Farias
Support type: Multi-user Equipment Program
FAPESP's process: 20/04579-7 - Study of the risk factors associated with greater severity to COVID-19 and mapping of the metabolic pathways required for the anti-SARS-CoV-2 response
Grantee:Pedro Manoel Mendes de Moraes Vieira
Support type: Regular Research Grants
FAPESP's process: 20/04746-0 - Understanding the molecular bases and the role of risk factors associated to SARS-CoV-2 infection in preclinical models
Grantee:Daniel Martins-de-Souza
Support type: Regular Research Grants
FAPESP's process: 20/02448-2 - The role of the presence of IRF-5 in dendritic cells, macrophages and B lymphocytes to control infection by the Oropouche virus in murine model
Grantee:Camila Lopes Simeoni
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 20/02159-0 - Antiviral activity of AAK1 inhibitors against Oropouche infection
Grantee:Karina Bispo dos Santos
Support type: Scholarships in Brazil - Master
FAPESP's process: 20/04583-4 - Impact of intestinal microbiota and its metabolites on SARS-CoV-2 infection
Grantee:Marco Aurélio Ramirez Vinolo
Support type: Regular Research Grants
FAPESP's process: 20/02312-3 - Study of the effect of short-chain fatty acids on the tissue regeneration process during experimental colitis
Grantee:Arilson Bernardo dos Santos Pereira Gomes
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/26908-0 - The role of IRF-5 in Oropouche virus pathogenesis and neurovirulence
Grantee:Pierina Lorencini Parise
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 20/04919-2 - Determining molecular candidates that contribute to the higher risk of COVID-19 in aged individuals
Grantee:Marcelo Alves da Silva Mori
Support type: Regular Research Grants
FAPESP's process: 19/14342-7 - Role of GPR43 receptor in intestinal epithelial cells and neutrophils during gut inflammation
Grantee:Patrícia Brito Rodrigues
Support type: Scholarships in Brazil - Doctorate