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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Brain Damage and Gene Expression Across Hereditary Spastic Paraplegia Subtypes

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Servelhere, Katiane R. [1] ; Ribeiro Rezende, Thiago Junqueira [1] ; de Lima, Fabricio Diniz [1] ; de Brito, Mariana Rabelo [1] ; de Franca Nunes, Renan Flavio [1] ; Casseb, Raphael F. [2] ; Pedroso, Jose Luiz [3] ; Barsottini, Orlando Graziani P. [3] ; Cendes, Fernando [1] ; Franca Jr, Marcondes C.
Total Authors: 10
[1] Univ Estadual Campinas, Dept Neurol, Sch Med Sci, UNICAMP, Campinas, SP - Brazil
[2] Univ Calgary, Seaman Family MR Res Ctr, Calgary, AB - Canada
[3] Fed Univ Sao Paulo UNIFESP, Dept Neurol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MOVEMENT DISORDERS; v. 36, n. 7 FEB 2021.
Web of Science Citations: 2

Background Spinal cord has been considered the main target of damage in hereditary spastic paraplegias (HSPs), but mounting evidence indicates that the brain is also affected. Despite this, little is known about the brain signature of HSPs, in particular regarding stratification for specific genetic subtypes. Objective We aimed to characterize cerebral and cerebellar damage in five HSP subtypes (9 SPG3A, 27 SPG4, 10 SPG7, 9 SPG8, and 29 SPG11) and to uncover the clinical and gene expression correlates. Methods We obtained high-resolution brain T1 and diffusion tensor image (DTI) datasets in this cross-sectional case-control study (n = 84). The MRICloud, FreeSurfer, and CERES-SUIT pipelines were employed to assess cerebral gray (GM) and white matter (WM) as well as the cerebellum. Results Brain abnormalities were found in all but one HSP group (SPG3A), but the patterns were gene-specific: basal ganglia, thalamic, and posterior WM involvement in SPG4; diffuse WM and cerebellar involvement in SPG7; cortical thinning at the motor cortices and pallidal atrophy in SPG8; and widespread GM, WM, and deep cerebellar nuclei damage in SPG11. Abnormal regions in SPG4 and SPG8 matched those with higher SPAST and WASHC5 expression, whereas in SPG7 and SPG11 this concordance was only noticed in the cerebellum. Conclusions Brain damage is a conspicuous feature of HSPs (even for pure subtypes), but the pattern of abnormalities is genotype-specific. Correlation between brain structural damage and gene expression maps is different for autosomal dominant and recessive HSPs, pointing to distinct pathophysiological mechanisms underlying brain damage in these subgroups of the disease. (c) 2021 International Parkinson and Movement Disorder Society (AU)

FAPESP's process: 17/13102-7 - Characterization and Comparison of Bayesian and Deep Learning based Methods for Cerebellar Segmentation
Grantee:Thiago Junqueira Ribeiro de Rezende
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
Grantee:Fernando Cendes
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC