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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reproductive toxicity in male juvenile rats: Antagonistic effects between isolated agrochemicals and in binary or ternary combinations

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Author(s):
Garcia, Mariana Simoes [1] ; de Carvalho Cavalcante, Deborah Navit [1] ; Araujo Santiago, Marcella da Silva [1] ; de Medeiros, Paloma Da Cunha [1] ; do Nascimento, Cinthia Castro [2] ; Camargo Fonseca, Gustavo Fernandes [1] ; Le Sueur-Maluf, Luciana [2] ; Perobelli, Juliana Elaine [1]
Total Authors: 8
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Inst Mar, Expt Toxicol Lab, Santos, SP - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Biociencias, Santos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY; v. 209, FEB 2021.
Web of Science Citations: 0
Abstract

The management of agrochemicals in Brazilian agriculture impacts global environmental sustainability and food security, since this country is one of the major agro-food exporters in the world. Acephate, carbendazim, and dithiocarbamates (DTCs) such as mancozeb, are among the most detected agrochemicals in Brazilian agro-food products, occurring in combination in several crops, especially in fruit cultures. The present study evaluated the impact of the exposure to isolated agrochemicals and all the combined possible mixtures (binary and ternary forms) on the reproductive parameters of male juvenile rats, known to be a vulnerable biological system and developmental window. Data were analyzed using Generalized Linear Models (GzLM), considering each agrochemical as an independent factor. The study revealed higher reproductive toxicity exerted by isolated agrochemicals when compared to the combined treatments, which exhibited mostly an antagonistic effect. Results suggest endocrine disruptive effects of each one separately on the weight of reproductive organs and testicular histomorphometry, besides changes in testicular SOD activity. The full factorial experimental design employed here allowed us to conclude that it is not possible to scale-up the effects of the isolated treatments to the mixtures, showing how difficult it is to know beforehand the response and cross-talk among the multiple physiological mechanisms disturbed by complex mixtures. Considering that food products are shared on a global scale and that some of these three agrochemicals have already been prohibited in EU countries, the consumption of some Brazilian products puts global human health at risk, that of children. (AU)

FAPESP's process: 17/23063-9 - Reproductive, endocrine, cytotoxic and genotoxic effects of acephate, carbendazim and mancozeb, isolated or in mixture: study of juvenile toxicity in rats
Grantee:Juliana Elaine Perobelli
Support Opportunities: Regular Research Grants