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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mathematical modelling, parameter estimation and computational simulation for skin wound healing under Copaiferalangsdorffi treatments

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Author(s):
de Oliveira, Marta H. [1, 2] ; Gushiken, Lucas F. S. [1, 3] ; Pellizzon, Claudia H. [1] ; Mancera, Paulo F. A. [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP - Brazil
[2] Biometr Grad Program, Botucatu, SP - Brazil
[3] Biotechnol Grad Program, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE; v. 199, FEB 2021.
Web of Science Citations: 0
Abstract

We present three mathematical models which simulate the wound healing time for 10% oil-resin (10% OR), 10% hydroalcoholic extract (10% EH) (Copaifera langsdorffii drugs), Lanette cream (LC) and Collage-nase treatments. Wound healing is a complex process consisting of inflammatory, proliferative and remodelling phases. The experiments were made on rats with wounds on their backs. The mathematical models consider the interplay among neutrophils, macrophages, which play an essential role in skin wound healing, pro-inflammatory (IL-6) and anti-inflammatory (IL-10) cytokines. The ordinary differential equations (ODE) models reproduce the cellular dynamics of wound healing on the skin, suggesting levels of macrophages and neutrophils cellularity, consistent with the values of total cellularity obtained in the laboratory. The partial differential equations (PDE) model replicate the dispersion along the wound radius, suggesting that the balance of the interleukins is better modelled on copaiba-based treatments (CBT). The cell density is directly influenced by neutrophils in the wound bed and by macrophages at the wound edge. It was possible to find the time for wound healing for all treatments by inserting the diffusive terms. (C) 2020 Published by Elsevier B.V. (AU)

FAPESP's process: 14/23684-5 - Evaluation of cellular and molecular mechanisms in skin wound healing using Copaifera langsdorffii hydroalcoholic extract and oil resin ointments
Grantee:Lucas Fernando Sérgio Gushiken
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/17600-1 - "Evaluation of the healing potential of topical formulations containing terpenes in rat skin wounds"
Grantee:Claudia Helena Pellizzon
Support Opportunities: Regular Research Grants