USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst

Author(s)

Alponti, Leonardo H. R. ^[1] ; Picinini, Monize ^[2] ; Urquieta-Gonzalez, Ernesto A. ^[2] ; Correa, Arlene G. ^[1]

Affiliation

^[1] Ctr Excellence Res Sustainable Chem, Dept Chem, Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem Engn, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Journal of Molecular Structure; v. 1227, MAR 5 2021.
• Web of Science Citations: 0

Abstract

The Hantzsch three-component reaction is the best-known multicomponent reaction, affording dihydropyridines which have been employed therapeutically and also as visible-light photoredox catalysts. In this work we report the application of an ultra-stable (US) Y zeolite as a promising green catalyst in the synthesis of a series of 1,4-dihydropyridines under microwave irradiation. Using the optimized reaction conditions, 21 compounds were prepared in 64-96% isolated yields. The recovery and recycle of the USY zeolite are also reported as well as its fully characterization. (C) 2020 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Grantee: Arlene Gonçalves Corrêa
• Support Opportunities: Research Grants - Research Centers in Engineering Program
• FAPESP's process: 18/12367-0 - Synthesis of nanocatalysts from biomass and use in multicomponent reactions
• Grantee: Leonardo Henrique Rondina Alponti
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC