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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use

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de Oliveira, Beatriz Ewert [1] ; Junqueira Amorim, Otavio Henrique [2] ; Lima, Loneta Lauro [2] ; Rezende, Rodrigo Alvarenga [2, 3] ; Mestnik, Natalia Cammarosano [4] ; Bagatin, Edileia [4] ; Leonardi, Gislaine Ricci [1]
Total Authors: 7
[1] Univ Campinas UNICAMP, Sch Pharmaceut Sci, Campinas, SP - Brazil
[2] Renato Archer Informat Technol Ctr CTI, Campinas, SP - Brazil
[3] Univ Araraquara Uniara, Postgrad Program Biotechnol, Araraquara, SP - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Review article
Web of Science Citations: 0

Background: 5-Fluorouracil (5-FU) is a well-known chemotherapy drug, used for over 70 years in the treatment of several types of cancer. Topically, 5-FU has shown potential effect to treat premalignant and malignant lesions. However, the efficiency of topical 5-FU administration is limited to treat superficial pre-carcinogenic lesions. Objective: In this review we present the main characteristics of 5-FU, including its mechanism of action, dissolution, and bioavailability. Moreover, we highlight the delivery systems under development that include 5-FU carriers in topical treatments. Results: Microemulsions and nanocarriers have demonstrated significant impact on the bioavailability of 5-FU in vitro and in vivo, increasing the drug effects on deeper layers of the skin, which has shown promising results in the treatment of precancemus and cancerous lesions. According to authors of clinical pilot studies, 5-FU occlusive dressing, 5-FU chemowrap, 5-FU transdermal, and their combination, resulting in a triple therapy, are more effective compared with cream formulation to treat precancer widespread in a skin area. Conclusion: Thus, by this review, we demonstrate that the delivery system under consideration greatly impacts 5-FU effects on the skin. (AU)

FAPESP's process: 18/20366-3 - Effect of 5-fluorouracil classical emulsion versus 5-fluorouracil manipulated in emulsion with hydrophilic polymer and high spreed homogenization on the cancerization field and advanced photoaging
Grantee:Ediléia Bagatin
Support Opportunities: Regular Research Grants