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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sex-Dependent Dyslipidemia and Neuro-Humoral Alterations Leading to Further Cardiovascular Risk in Juvenile Obesity

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Author(s):
Simoes, Estefania [1] ; Correia-Lima, Joanna [1] ; Calfat, Elie Leal de Barros [2] ; Otani, Thais Zelia dos Santos [2] ; Vasques, Daniel Augusto Correa [2] ; Otani, Victor Henrique Oyamada [2] ; Bertolazzi, Pamela [2] ; Kochi, Cristiane [3] ; Seelaender, Marilia [4, 1, 5] ; Uchida, Ricardo Riyoiti [2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Canc Metab Res Grp, Sao Paulo - Brazil
[2] Santa Casa Sao Paulo Sch Med Sci, Mental Hlth Dept, Sao Paulo - Brazil
[3] Santa Casa Sao Paulo Sch Med Sci, Physiol Dept, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil
[5] Hosp Clin Univ Sao Paulo, Lab Invent Med 26, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: FRONTIERS IN NUTRITION; v. 7, FEB 12 2021.
Web of Science Citations: 0
Abstract

Objective: Childhood obesity is a growing concern as the World Health Organization (WHO) states that similar to 10% of adolescents worldwide are overweight or obese. This condition is the reflex of energy imbalance between the calories consumed and those expended. Sex-related responses associated with dyslipidemia, hormonal alterations, and neuro-humoral disruptions in childhood obesity are the focus of the present investigation. Methods: Ninety-two Brazilian adolescents were enrolled and divided between obese and eutrophic groups. Obesity was assessed using body mass index Z-score according to age and weight. Anthropometrical analyses, blood pressure, blood lipids, metabolism-regulating hormones, and neuropeptides were carried out. Results: Systolic blood pressure was higher in female and male patients with obesity. Obese females presented alterations in lipid profile and an augment of cardiovascular disease prediction ratios TC/HDL, TG/HDL, LDL/HDL, and VLDL/HDL. The levels of leptin, GIP, and neuropeptide showed sex-dimorphism in obesity. The obese adolescents presented increased levels of circulating insulin, c-peptide, amylin, glucagon, and GLP-1. Correlation analysis showed significant linearity between body mass index, blood pressure, lipids, lipoproteins, hormones, and neuropeptides content. Conclusions: Our data support an existing link associating hypertension, dyslipidemia, and neuro-hormonal imbalance in childhood obesity. We also described a sex-dependent pattern in childhood obesity-associated dyslipidemia and blood pressure in female patients with obesity solely. (AU)

FAPESP's process: 12/50079-0 - Systemic inflammation in cachectic cancer patients: mechanisms and therapeutical strategies, a translational medicine approach
Grantee:Marilia Cerqueira Leite Seelaender
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/21677-6 - Cerebral anatomy, inflammatory mediators and appetite regulatory hormones in obese pediatrics patients: a neurobiology study of obesity
Grantee:Ricardo Riyoiti Uchida
Support Opportunities: Regular Research Grants