Phenolic compounds from jaboticaba (Plinia jabotic... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) ameliorate intestinal inflammation and associated endotoxemia in obesity

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Author(s):
Rodrigues, Larissa [1] ; Donado-Pestana, Carlos M. [1] ; Moura, Marcio H. C. [1] ; Rossi e Silva, Rafaela [1] ; Pessoa, Erika V. M. [1] ; Genovese, Maria Ines [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Alimentos & Nutr Expt, Ave Prof Lineu Prestes, 580, Bloco 14, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Food Research International; v. 141, MAR 2021.
Web of Science Citations: 0
Abstract

Jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian native fruit belonging to the Myrtaceae family. Previously it was demonstrated that phenolic-rich extracts from jaboticaba (PEJ) possess health-beneficial properties in diet-induced obesity; however, whether PEJ modulates the obesity-associated intestinal inflammatory status remains unclear. Thus, male C57BL/6J obese mice were fed a high-fat-sugar (HFS) diet and received PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) (PEJ1 group), and 100 mg GAE/kg BW (PEJ2 group), or water (HFS group) by oral gavage for 14 weeks. PEJ groups presented a reduced body weight gain and adiposity and were protected against insulin resistance and dyslipidemia. In addition, PEJ prevented metabolic endotoxemia linked to an attenuation of the HFS diet-induced intestinal inflammation via down-regulation of pro-inflammatory mediators such as tumor necrosis factor (TNF-alpha), membrane transporter toll-like receptor-4 (TLR-4) and nuclear factor-kappa B (NF-kappa B) in the colon. These anti-inflammatory effects appear to be involved, at least in part, with an inhibition of the colonic inflammasome pathway of obese mice. (AU)

FAPESP's process: 18/24477-4 - Modulation of intestinal microbiota and tissue proteomic analyses in obesity-induced inflammation and insulin resistance: Role of polyphenols from Brazilian native Myrtaceae fruits
Grantee:Maria Ines Genovese Rodriguez
Support Opportunities: Regular Research Grants