Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit

Full text
de Almeida, Jr., Joao N. [1, 2, 3] ; Francisco, Elaine C. [1] ; Hagen, Ferry [4, 5] ; Brandao, Igor B. [6] ; Pereira, Felicidade M. [7] ; Presta Dias, Pedro H. [8] ; de Miranda Costa, Magda M. [9] ; de Souza Jordao, Regiane T. [10] ; de Groot, Theun [11] ; Colombo, Arnaldo L. [1]
Total Authors: 10
Show less -
[1] Univ Fed Sao Paulo, Disciplina Infectol, Lab Especial Micol, BR-04039032 Sao Paulo - Brazil
[2] Hosp Clin Univ Sao Paulo, Div Lab Cent, BR-01246100 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Med Trop, BR-01246100 Sao Paulo - Brazil
[4] Westerdijk Fungal Biodivers Inst, NL-3508 AD Utrecht - Netherlands
[5] Univ Med Ctr Utrecht, Dept Med Microbiol, NL-3584 CS Utrecht - Netherlands
[6] Hosp Bahia, Comissao Controle Infeccao Hosp, BR-41810011 Salvador, BA - Brazil
[7] Lab Cent Saude Publ Prof Goncalo Muniz, BR-40295010 Salvador, BA - Brazil
[8] Ctr Informacoes Estrateg Vigilancia Saude, BR-40279120 Salvador, BA - Brazil
[9] Agencia Nacl Vigilancia Sanitaria, BR-71205050 Brasilia, DF - Brazil
[10] Minist Saude, Coordenacao Geral Labs Saude Publ, BR-70058900 Brasilia, DF - Brazil
[11] Canisius Wilhelmina Hosp CWZ, Dept Med Microbiol & Infect Dis, NL-6532 SZ Nijmegen - Netherlands
Total Affiliations: 11
Document type: Journal article
Source: JOURNAL OF FUNGI; v. 7, n. 3 MAR 2021.
Web of Science Citations: 0

In December 2020, Candida auris emerged in Brazil in the city of Salvador. The first two C. auris colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 mu g/mL, 2 mu g/mL, 0.03 mu g/L, and 0.06 mu g/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade C. auris. The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area. (AU)

FAPESP's process: 18/19347-4 - Characterization of molecular mechanisms related to azoles resistance in Trichosporon asahii clinical isolates
Grantee:João Nóbrega de Almeida Júnior
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 17/02203-7 - Multidisciplinary and international network to characterize microbiological aspects and natural history of invasive fungal infections due Candida spp
Grantee:Arnaldo Lopes Colombo
Support Opportunities: Research Projects - Thematic Grants