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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

4-Aminoquinoline compounds from the Spanish flu to COVID-19

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Bazotte, Roberto Barbosa [1] ; Hirabara, Sandro Massao [2] ; Duarte Serdan, Tamires Afonso [2] ; Gritte, Raquel Bragante [2] ; Souza-Siqueira, Talita [2] ; Gorjao, Renata [2] ; Masi, Laureane Nunes [2] ; Antunes, Marina Masetto [1] ; Cruzat, Vinicius [3] ; Pithon-Curi, Tania Cristina [2] ; Curi, Rui [2]
Total Authors: 11
[1] Univ Estadual Maringa, Dept Pharmacol & Therapeut, Maringa, PR - Brazil
[2] Univ Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, Sao Paulo, SP - Brazil
[3] Torrens Univ Australia, Fac Hlth, Melbourne, Vic - Australia
Total Affiliations: 3
Document type: Review article
Web of Science Citations: 0

In 1918, quinine was used as one of the unscientifically based treatments against the H1N1 virus during the Spanish flu pandemic. Originally, quinine was extracted from the bark of Chinchona trees by South American natives of the Amazon forest, and it has been used to treat fever since the seventeenth century. The recent COVID-19 pandemic caused by Sars-Cov-2 infection has forced researchers to search for ways to prevent and treat this disease. Based on the antiviral potential of two 4-aminoquinoline compounds derived from quinine, known as chloroquine (CQ) and hydroxychloroquine (HCQ), clinical investigations for treating COVID-19 are being conducted worldwide. However, there are some discrepancies among the clinical trial outcomes.Thus, even after one hundred years of quinine use during the Spanish flu pandemic, the antiviral properties promoted by 4aminoquinoline compounds remain unclear. The underlying molecular mechanisms by which CQ and HCQ inhibit viral replication open up the possibility of developing novel analogs of these drugs to combat COVID-19 and other viruses. (AU)

FAPESP's process: 19/25936-5 - Research Contingency Fund for Institutional Infraestructure of the Cruzeiro do Sul University - 2019
Grantee:Tania Cristina Pithon Curi
Support Opportunities: Research Grants - Technical Reserve for Institutional Research Infrastructure
FAPESP's process: 18/09868-7 - Cellular and molecular mechanisms of insulin resistance and inflammation in obese Wistar rats and lean Goto-Kakizaki rats: causes and associations with diet and physical exercise
Grantee:Rui Curi
Support Opportunities: Research Projects - Thematic Grants