Poor physical activity levels and cardiorespiratory fitness among patients with childhood-onset takayasu arteritis in remission: a cross-sectional, multicenter study

Author(s):Show less -

Astley, Camilla ^{[1, 2]} ; Gil, Saulo ^[1] ; Clemente, Gleice ^[3] ; Terreri, Maria Teresa ^[3] ; Silva, Clovis Artur ^[4] ; Arruda Campos, Lucia Maria ^[4] ; Aikawa, Nadia Emi ^[4] ; de Sa Pinto, Ana Lucia ^{[1, 2]} ; Pereira, Rosa Maria R. ^[2] ; Roschel, Hamilton ^{[1, 2]} ; Gualano, Bruno ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Fac Med FMUSP, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Rheumatol Div, Fac Med FMUSP, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Div Paediat Rheumatol, Dept Paediat, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Paediat Rheumatol Unit, Children & Adolescents Inst, Fac Med FMUSP, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: PEDIATRIC RHEUMATOLOGY; v. 19, n. 1 MAR 22 2021.
• Web of Science Citations: 0

Abstract

BackgroundIt is currently unknown whether patients with childhood-onset Takayasu disease (c-TA) are prone to physical inactivity and poor aerobic capacity. In this study, we assessed physical activity levels and cardiorespiratory fitness along with health-related quality of life (HRQL) and various traditional and non-traditional risk factors in patients with c-TA vs. healthy controls.Methodsc-TA patients with non-active disease (n=17) and age- and sex-matched healthy controls (n=17) were enrolled in the study. We assessed physical activity levels, aerobic capacity, body composition, systemic inflammation, cardiometabolic markers, disease-related parameters, and HRQL.Resultsc-TA patients showed greater time spent in sedentary behavior (P=0.010), and lower moderate-to-vigorous physical activity (P>0.001) and lower step counts per day (P>0.001). VO2peak (P<0.001) and chronotropic response (P=0.016) were significantly lower in patients with c-TA and they had worse HRQL in physical domain (P<0.001), lower bone mineral content and density, and higher insulin levels vs. healthy controls (all P <= 0.05).Conclusionsc-TA patients exhibited reduced physical activity levels and aerobic capacity, worse cardiometabolic risk factors and HRQL parameter compared with healthy peers. Physical inactivity and aerobic deconditioning emerge as potentially novel risk factors for c-TA. The role of physical activity interventions in preventing poor outcomes and improving HRQL in c-TA remains to be explored. (AU)

• FAPESP's process: 17/07358-9 - Physical activity in patients with Juvenile Takayasu Arteritis: Clinical effects and mechanisms of action.
• Grantee: Camilla Astley Amaral Pedroso
• Support Opportunities: Scholarships in Brazil - Master