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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The impact of P/Ca molar ratio on physicochemical and release properties of calcium polyphosphate coacervates

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Author(s):
de Paiva, Juliana Moreno [1] ; de Oliveira Barud, Helida Gomes [2] ; Franco, Douglas Faza [1] ; Meneguin, Andreia Bagliotti [2] ; Ribeiro, Antonio Jose [3] ; Barud, Hernane S. [4] ; Nalin, Marcelo [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Araraquara, SP - Brazil
[2] BioSmart Nanotechnol LTDA, Ave Jorge Fernandes de Sao Mattos 311, BR-14808162 Araraquara, SP - Brazil
[3] Univ Coimbra, Fac Pharm, Coimbra - Portugal
[4] Univ Araraquara, Lab Biopolimeros & Biomat, UNIARA, BR-14801340 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Materials Chemistry and Physics; v. 264, MAY 1 2021.
Web of Science Citations: 0
Abstract

This paper reports on the synthesis and characterization of gel-like calcium polyphosphate coacervates (Ca-PPCs) with three different {[}P]:{[}Ca] ratios as new matrixes for drug release. Caffeine and chlorhexidine were used as model drugs, showing encapsulation efficiency of up to 95.4% and 70.4%, respectively. Based on the correlation coefficient (r(2)) values, different in vitro release behaviors were determined. While the caffeine release followed the Weibull model, the chlorhexidine release was best described by the Korsmeyer-Peppas model. The caffeine-loaded coacervate sample with the highest Ca2+ concentration (CAFPCa0.5) showed the highest incorporation and a total drug release within 720 min. The Ca-PPC-drug interactions were evaluated by infrared and Raman spectroscopies. The Ca2+ concentration, drug molecule size and intermolecular drug/matrix interactions determined the incorporation and release of drugs in the polyphosphate coacervates. High calcium concentration led to a Ca-PPC with small and tight ``cage-like{''} structure that better incorporated caffeine molecules because of their 4.3 times smaller size compared to chlorhexidine. In addition, caffeine interacted through van der Waals' forces with polyphosphate and its release from the coacervates was most likely to occur in relation to chlorhexidine, which interacted with the coacervates through hydrogen bonding. Thus, the calcium polyphosphate coacervates loaded with the proposed drugs can be competitive and promising as drug delivery systems. (AU)

FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/25512-8 - Biocelulose-based Cell Culture Platform
Grantee:Hernane da Silva Barud
Support type: Regular Research Grants
FAPESP's process: 18/24735-3 - The correlation between structure and properties as investigated by multinuclear solid state NMR in disordered materials
Grantee:Silvia Helena Santagneli
Support type: Regular Research Grants