Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Salivary BPIFA proteins are altered in patients undergoing hematopoietic cell transplantation

Full text
Innocentini, Lara Maria Alencar Ramos [1] ; Silva, Andreia Aparecida [2] ; Carvalho, Marco Antonio [2] ; Coletta, Ricardo D. [2] ; Correa, Maria Elvira Pizzigatti [3] ; Bingle, Lynne [4] ; Bingle, Colin D. [5] ; Vargas, Pablo Agustin [2] ; Lopes, Marcio Ajudarte [2]
Total Authors: 9
[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dent & Stomatol Div, Clin Hosp, Ophthalmol Otolaryngol & Head & Neck Su, Ribeirao Preto - Brazil
[2] Univ Campinas FOP UNICAMP, Sch Dent Piracicaba, Dept Oral Diag, Piracicaba, SP - Brazil
[3] Univ Estadual Campinas, Hematol & Blood Transfus Ctr, Sao Paulo - Brazil
[4] Univ Sheffield, Sch Clin Dent, Dept Oral & Maxillofacial Pathol, Sheffield, S Yorkshire - England
[5] Univ Sheffield, Dept Infect & Immun, Acad Unit Resp Med, Sheffield, S Yorkshire - England
Total Affiliations: 5
Document type: Journal article
Source: ORAL DISEASES; APR 2021.
Web of Science Citations: 0

Objective The aim of this study was to evaluate the expression of BPIFA proteins in the saliva and salivary glands of hematopoietic cell transplant (HCT) patients. Material and Methods This longitudinal study included patients who had undergone autologous HCT (auto-HCT) and allogeneic HCT (allo-HCT), and unstimulated saliva was collected at three time points, with a fourth collection at oral chronic graft-versus-host disease (cGVHD) onset. BPIFA expression was analysed by Western blotting in saliva and immunostaining in the minor salivary glands of cGVHD patients. Results Auto-HCT patients showed increased levels of BPIFA1 (p = .021) and BPIFA2 at D+7 (p = .040), whereas allo-HCT group demonstrated decreased expression of BPIFA2 at D+8 (p = .002) and at D+80 (p = .001) and a significant association between BPIFA2 low levels and hyposalivation was observed (p = .02). BPIFA2 was significantly lower in the cGVHD patients when compared to baseline (p = .04). Conclusions The results of this study show distinct pattern of expression of BPIF proteins in both auto-HCT and allo-HCT recipients with decreased levels of BPIFA2 during hyposalivation and cGVHD. Further studies are necessary to elucidate these proteins mechanisms and their clinical implications in these groups of patients. (AU)

FAPESP's process: 11/07853-3 - Evaluation of plunc family proteins expression in patients with GVHD, HSCT, head and neck cancer
Grantee:Pablo Agustin Vargas
Support type: Regular Research Grants
FAPESP's process: 11/00711-9 - Clinical laboratory study of patients who will receive chemotherapy
Grantee:Lara Maria Alencar Ramos Innocentini
Support type: Scholarships in Brazil - Doctorate