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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Morphogenesis of the lens placode

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Author(s):
Magalhaes, Cecilia G. [1] ; De Oliveira-Melo, Maraysa [2] ; Yan, C. Y. Irene [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, SP - Brazil
[2] Univ Estadual Campinas, Biol Inst, Dept Struct & Funct Biol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY; v. 65, n. 4-6, 2, p. 235-244, 2021.
Web of Science Citations: 0
Abstract

For over 100 years, the vertebrate eye has been an important model system to understand cell induction, cell shape change, and morphogenesis during development. In the past, most of the studies examined histological changes to detect the presence of induction mechanisms, but the advancement of molecular biology techniques has made exploring the genetic mechanisms behind lens development possible. Despite the particular emphasis given to the induction of the lens placode, there are still many aspects of the cell biology of lens morphogenesis to be explored. Here, we will revisit the classical detailed description of early lens morphological changes, correlating it with the cell biology mechanisms and with the molecules and signaling pathways identified up to now in chick and mouse embryos. A detailed description of lens development stages helps better understand the timeline of the events involved in early lens morphogenesis. We then point to some key questions that are still open. (AU)

FAPESP's process: 17/07405-7 - MORPHOLOGICAL AND TRANSCRIPTIONAL CHANGES IN EARLY NEURAL EMBRYOGENESIS
Grantee:Chao Yun Irene Yan
Support type: Regular Research Grants