Birth cohort-specific trends of sun-related behaviors among individuals from an international consortium of melanoma-prone families

Author(s):Show less -

Lacson, John Charles A. ^[1] ; Zamani, Shawn A. ^{[1, 2]} ; Froes Jr, Luis Alberto Ribeiro ; Mitra, Nandita ^[3] ; Qian, Lu ^[4] ; Doyle, Scarlet H. ^[1] ; Azizi, Esther ^{[5, 6]} ; Balestrini, Claudia ^[7] ; Bishop, D. Timothy ^[8] ; Bruno, William ^[9] ; Carlos-Ortega, Blanca ^[10] ; Cuellar, Francisco ^{[11, 12]} ; Cust, Anne E. ^{[13, 14]} ; Elder, David E. ^[15] ; Gerdes, Anne-Marie ^[16] ; Ghiorzo, Paola ^{[9, 17]} ; Grazziotin, Thais C. ^[18] ; Gruis, Nelleke A. ^[19] ; Hansson, Johan ^[20] ; Hocevar, Marko ^[21] ; Hoiom, Veronica ^[20] ; Holland, Elizabeth A. ^[22] ; Ingvar, Christian ^{[23, 24]} ; Landman, Gilles ^{[25, 26]} ; Larre-Borges, Alejandra ^[27] ; Mann, Graham J. ^{[14, 22, 28]} ; Molgo, Montserrat ^[29] ; Moredo, Luciana Facure ^[30] ; Olsson, Hakan ^{[23, 24]} ; Out-Luiting, Jacoba J. ^[19] ; Peric, Barbara ^[21] ; Pjanova, Dace ^[31] ; Puig, Susana ^{[32, 11, 33]} ; Salas-Alanis, Julio ^{[10, 34]} ; Schmid, Helen ^[22] ; Wadt, Karin A. W. ^[16] ; Newton-Bishop, Julia A. ^[8] ; Kanetsky, Peter A. ^[1] ; Grp, GenoMEL Study

Affiliation:Show less -

^[1] H Lee Moffitt Canc Ctr & Res Inst, Div Populat Sci, Dept Canc Epidmiol, 12902 Magnolia Dr, MRC 213, Tampa, FL 33612 - USA

^[2] Univ Cambridge, Med Res Council, Div Clin Med, Canc Unit, Cambridge, Cambs - England

^[3] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 - USA

^[4] Fred Hutchinson Canc Res Ctr, SWOG Stat & Data Management Ctr, Publ Hlth Sciences Div, Seattle, WA - USA

^[5] Sheba Med Ctr, Dept Dermatol, Tel Hashomer - Israel

^[6] Tel Aviv Univ, Sackler Fac Med, Tel Aviv - Israel

^[7] Hosp Dr Sotero del Rio, Serv Dermatol, Santiago - Chile

^[8] Univ Leeds, Inst Med Res St Jamess, Leeds, W Yorkshire - England

^[9] Univ Genoa, Dept Internal Med & Med Specialties, Genoa - Italy

^[10] Escuela Med Univ Monterrey, Dept Ciencias Bas, Monterrey - Mexico

^[11] Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer, Dermatol Dept, Melanoma Unit, IDIBAPS, Barcelona - Spain

^[12] CONACYT, Ciudad De Mexico, Mexico - Mexico

^[13] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW - Australia

^[14] Univ Sydney, Melanoma Inst Australia, Wollstonecraft, NSW - Australia

^[15] Hosp Univ Penn, Dept Pathol, Lab Med, Philadelphia, PA - USA

^[16] Univ Hosp Copenhagen, Dept Clin Genet, Copenhagen - Denmark

^[17] IRCCS Osped Policlin San Martino, Genet Rare Canc, Genoa - Italy

^[18] Pontificia Univ Catolica Rio Grande, PUCRS, Porto Alegre, RS - Brazil

^[19] Leiden Univ, Dept Dermatol, Med Ctr, Leiden - Netherlands

^[20] Karolinska Inst, Dept Oncol, Stockholm - Sweden

^[21] Inst Oncol Ljubljana, Ljubljana - Slovenia

^[22] Univ Sydney, Westmead Inst Med Res, Westmead, NSW - Australia

^[23] Lund Univ Hosp, Dept Clin Sci, Lund - Sweden

^[24] Lund Univ Hosp, Dept Surg, Lund - Sweden

^[25] Univ Fed Sao Paulo, Dept Pathol, Escola Paulista Med, Sao Paulo - Brazil

^[26] Camargo Canc Ctr, Dept Pathol, Sao Paulo - Brazil

^[27] Univ Republica, Hosp Clin, Unidad Les Pigmentadas, Catedra Dermatol, Montevideo - Uruguay

^[28] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT - Australia

^[29] Pontificia Univ Catolica Chile, Santiago - Chile

^[30] Camargo Canc Ctr, Skin Canc Dept, Sao Paulo - Brazil

^[31] Latvian Biomed Res & Study Ctr, Riga - Latvia

^[32] Univ Barcelona, Dept Med, Barcelona - Spain

^[33] Inst Salud Carlos 3, CIBERER, Barcelona - Spain

^[34] Dystroph Epidermolysis Bullous Res Assoc Mexico, Monterrey - Mexico

• Document type: Journal article
• Source: BMC PUBLIC HEALTH; v. 21, n. 1 APR 23 2021.
• Web of Science Citations: 0

Abstract

Background Individuals from melanoma-prone families have similar or reduced sun-protective behaviors compared to the general population. Studies on trends in sun-related behaviors have been temporally and geographically limited. Methods Individuals from an international consortium of melanoma-prone families (GenoMEL) were retrospectively asked about sunscreen use, sun exposure (time spent outside), sunburns, and sunbed use at several timepoints over their lifetime. Generalized linear mixed models were used to examine the association between these outcomes and birth cohort defined by decade spans, after adjusting for covariates. Results A total of 2407 participants from 547 families across 17 centers were analyzed. Sunscreen use increased across subsequent birth cohorts, and although the likelihood of sunburns increased until the 1950s birth cohort, it decreased thereafter. Average sun exposure did not change across the birth cohorts, and the likelihood of sunbed use increased in more recent birth cohorts. We generally did not find any differences in sun-related behavior when comparing melanoma cases to non-cases. Melanoma cases had increased sunscreen use, decreased sun exposure, and decreased odds of sunburn and sunbed use after melanoma diagnosis compared to before diagnosis. Conclusions Although sunscreen use has increased and the likelihood of sunburns has decreased in more recent birth cohorts, individuals in melanoma-prone families have not reduced their overall sun exposure and had an increased likelihood of sunbed use in more recent birth cohorts. These observations demonstrate partial improvements in melanoma prevention and suggest that additional intervention strategies may be needed to achieve optimal sun-protective behavior in melanoma-prone families. (AU)

• FAPESP's process: 07/04313-2 - Genetic and environmental risk factors to the development of melanoma in Latin America
• Grantee: Gilles Landman
• Support Opportunities: Regular Research Grants