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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative Analysis of Virulence Mechanisms of Trypanosomatids Pathogenic to Humans

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Author(s):
de Castro Neto, Artur Leonel [1] ; da Silveira, Jose Franco [1] ; Mortara, Renato Arruda [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 11, APR 16 2021.
Web of Science Citations: 2
Abstract

Trypanosoma brucei, Leishmania spp., and T. cruzi are flagellate protozoans of the family Trypanosomatidae and the causative agents of human African trypanosomiasis, leishmaniasis, and Chagas disease, respectively. These diseases affect humans worldwide and exert a significant impact on public health. Over the course of evolution, the parasites associated with these pathologies have developed mechanisms to circumvent the immune response system throughout the infection cycle. In cases of human infection, this function is undertaken by a group of proteins and processes that allow the parasites to propagate and survive during host invasion. In T. brucei, antigenic variation is promoted by variant surface glycoproteins and other proteins involved in evasion from the humoral immune response, which helps the parasite sustain itself in the extracellular milieu during infection. Conversely, Leishmania spp. and T. cruzi possess a more complex infection cycle, with specific intracellular stages. In addition to mechanisms for evading humoral immunity, the pathogens have also developed mechanisms for facilitating their adhesion and incorporation into host cells. In this review, the different immune evasion strategies at cellular and molecular levels developed by these human-pathogenic trypanosomatids have been discussed, with a focus on the key molecules responsible for mediating the invasion and evasion mechanisms and the effects of these molecules on virulence. (AU)

FAPESP's process: 19/23302-9 - Characterization of components secreted by Trypanosoma cruzi extracellular amastigotes and their effect on cell invasion
Grantee:Artur Leonel de Castro Neto
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/15000-4 - Trypanosoma cruzi: intra and interspecific genomic variability and mechanisms of cell invasion/egress
Grantee:Renato Arruda Mortara
Support Opportunities: Research Projects - Thematic Grants