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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Serum Creatinine as a Potential Biomarker of Skeletal Muscle Atrophy in Non-small Cell Lung Cancer Patients

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Author(s):
das Neves, Willian [1] ; Alves, Christiano R. R. [2] ; de Souza Borges, Ana Paula [1] ; de Castro Jr, Gilberto
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin HC FMUSP, Inst Canc Estado Sao Paulo ICESP, Sao Paulo - Brazil
[2] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 - USA
Total Affiliations: 2
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, APR 12 2021.
Web of Science Citations: 0
Abstract

Objectives: Identifying simple biomarkers to determine muscle atrophy in non-small-cell lung cancer (NSCLC) patients remains a critical research gap. Since creatinine is mainly a product from intramuscular creatine metabolism, we tested the hypothesis that low serum creatinine levels would be associated to skeletal muscle atrophy in NSCLC patients. Materials and Methods: This is a prospective cohort study including 106 treatment-naive patients with histologically confirmed stage IV NSCLC. All patients performed routine serum creatinine laboratory tests. We divided patients into two groups based on low (<0.7 mg/dL for male and <0.5 mg/dL for female) or normal creatinine levels. We compared body mass index (BMI), psoas muscle cross-sectional area, adipose tissue area and complete blood counts between groups. Results: Male and female NSCLC patients with low serum creatinine levels had low muscle cross-sectional area as compared to patients with normal serum creatinine levels. Male NSCLC patients with low serum creatinine also displayed reduced BMI, reduced adipose tissue area, and elevated systemic inflammation compared to NSCLC patients with normal serum creatinine levels. There were no significant differences between female groups for BMI, adipose tissue area and inflammatory markers. Conclusions: Serum creatinine is a potential prognostic biomarker of skeletal muscle atrophy in NSCLC patients. Since serum creatinine is a simple and accessible measurement, we suggest that it should be monitored in longitudinal follow-up of NSCLC patients as a biomarker of muscle atrophy. (AU)

FAPESP's process: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/03016-8 - Cancer cachexia: effects of aerobic physical training on skeletal muscle in animal model
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/25240-1 - Effects of high-intensity interval training on skeletal muscle of Walker 256 tumor-bearing rats
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 12/02528-0 - Effects of high-intensity physical training on skeletal muscle of Walker 256 tumor-bearing rats
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/01478-0 - Molecular mechanisms underlying cancer cachexia: exploring the role of COPS2
Grantee:Christiano Robles Rodrigues Alves
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)