Meccatti, Vanessa M.
De Oliveira, Jonatas R.
Figueira, Leandro W.
Netto, Amandio A. Lagareiro
Zamarioli, Lucas S.
Marcucci, Maria C.
Camargo, Samira E. A.
Carvalho, Claudio A. T.
De Oliveira, Luciane D.
Total Authors: 9
 Univ Estadual Paulista UNESP, Inst Ciencia & Tecnol, Dept Biociencias & Diagnost Bucal, Av Engenheiro Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
 Univ Anhembi Morumbi, Escola Med, Av Dep Benedito Matarazzo 4050, BR-12230002 Sao Jose Dos Campos, SP - Brazil
 Univ Anhanguera, Dept Farm, Av Raimundo Pereira de Magalhaes 3305, BR-05145200 Sao Paulo, SP - Brazil
 Univ Fed Sao Paulo UNIFESP, Inst Farmacol & Biol Mol, Dept Modo Acao Drogas, Rua Tres de Maio 100, BR-04044020 Sao Paulo, SP - Brazil
 Univ Estadual Paulista UNESP, Inst Ciencia & Tecnol, Dept Odontol Restauradora, Av Engenheiro Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 6
Anais da Academia Brasileira de Ciências;
Web of Science Citations:
Abstract Candida spp. are naturally opportunistic and can promote infections. These yeasts can form biofilm, after penetration and adhesion to the biotic or abiotic surfaces. Preexisting diseases, treatments with drugs and radiation therapy, medical procedures, and parafunctional habits favor the installation of a fungal infection. Increased resistance to the available antifungals has become a concern. Therefore, alternative methods to control them have been evaluated, including the use of plant substances. In this study, the antibiofilm effect of R. officinalis L. extract was analyzed on C. albicans, C. dubliniensis, C. glabrata, C. krusei, and C. tropicalis. A phytochemical analysis of the extract was performed. Biofilms were formed for 48 h and exposed to the different concentrations of the extract (50, 100, and 200 mg/mL) for 5 min or 24 h. The effect of the plant extract was compared to the antifungal nystatin. Rosmarinus officinalis L. extract was constituted of phenols and flavonoids, highlighting the presence of chlorogenic acid derivatives in its composition. Biofilm reductions were observed after exposure to the plant extract for both periods. The plant extract provided a reduction similar to the antifungal. Thus, R. officinalis L. extract showed antibiofilm effect on Candida spp. comparable to the nystatin. (AU)