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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Assessing the effects of diagnostic sensitivity on schistosomiasis dynamics

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Vilches, Thomas N. [1] ; Graeff-Teixeira, Carlos [2] ; Yang, Hyun Mo [1]
Total Authors: 3
[1] IMECC Unicamp, Campinas, SP - Brazil
[2] NDI CCS UFES, Vitoria, ES - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Theoretical Biology; v. 523, AUG 21 2021.
Web of Science Citations: 0

Schistosomiasis is a parasite infection that affects millions of people around the world. It is endemic in 13 different states in Brazil and responsible for increasing morbidity in the population. One of its main characteristics is a heterogeneous distribution of worm burden in the human population, which makes the diagnosis difficult. We aimed to investigate how the sensitivity of the diagnostic method may contribute to successful control interventions against infections in a population. In order to do that, we present an ordinary differential equations model that considers three levels of worm burden in the human population, a snail population, and a miracidium reservoir. Through a steady-state analysis and its local stability, we show how this worm-burden heterogeneity can be responsible for the persistence of infection, especially due to reinfection in the highest level of worm burden. The analysis highlights sensitive diagnosis, besides treatment and sanitary improvements, as a key factor for schistosomiasis transmission control. (C) 2021 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 18/24811-1 - Mathematical modelling for the transmission of schistosomiasis in low-prevalence areas
Grantee:Thomas Nogueira Vilches
Support type: Scholarships in Brazil - Post-Doctorate