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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of PTEN signaling in synaptic function: Implications in autism spectrum disorder

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Nagy, Gabriela Spina [1] ; Kawamoto, Elisa Mitiko [1] ; Bridi, Jessika Cristina [1]
Total Authors: 3
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Lab Mol & Funct Neurobiol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Neuroscience Letters; v. 759, AUG 10 2021.
Web of Science Citations: 0

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates several cellular processes including survival, proliferation, and metabolism. In the brain, PTEN is a key modulator of synaptic function, and is involved in regulating synaptogenesis, connectivity, and synaptic plasticity. Herein we discuss how alterations in PTEN can disturb these mechanisms, thus compromising normal synaptic function and consequently contributing to behavioral and cognitive phenotypes observed in autism spectrum disorder (ASD). As the role of PTEN in synaptic function is linked to ASD, a deeper understanding of this interaction will shed light on the pathological mechanisms involved in ASD, contributing to the development of new therapies. (AU)

FAPESP's process: 20/08005-5 - Evaluation of PTEN modulation on glutamatergic signaling in neuroinflammation model
Grantee:Gabriela Spina Nagy
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/07427-8 - Aging and neuroprotection: effects of Klotho protein in energetic metabolism, Na,K-ATPase signaling and adaptative response in central nervous system
Grantee:Cristoforo Scavone
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/12974-6 - Evaluation of PTEN inhibition and compartmentalization effects in the presence of neuroinflammation: participation of glutamatergic signaling
Grantee:Elisa Mitiko Kawamoto Iwashe
Support Opportunities: Regular Research Grants
FAPESP's process: 19/10044-1 - Study of the modulator role of Klotho protein in neuroinflammatory signaling in mice
Grantee:Jessika Cristina Bridi
Support Opportunities: Scholarships in Brazil - Post-Doctoral