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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modulatory effects of photobiomodulation in the anterior cingulate cortex of diabetic rats

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Correia Rocha, Igor Rafael [1] ; Chacur, Marucia [1]
Total Authors: 2
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Anat, Ave Lineu Prestes 2415, Room 007, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 0

Anterior Cingulate Cortex (ACC) has a crucial contribution to higher order pain processing. Photobiomodulation (PBM) has being used as integrative medicine for pain treatment and for a variety of nervous system disorders. This study evaluated the effects of PBM in the ACC of diabetic rats. Type 1 diabetes was induced by a single dose of streptozotocin (85 mg/Kg). A total of ten sessions of PBM (pulsed gallium-arsenide laser, 904 nm, 9500 Hz, 6.23 J/cm(2)) was applied to the rat peripheral nervous system. Glial fibrillary acidic protein (GFAP), mu-opioid receptor (MOR), glutamate receptor 1 (GluR1), and glutamic acid decarboxylase (GAD65/67) protein level expression were analyzed in the ACC of diabetic rats treated with PBM. Our data revealed that PBM decreased 79.5% of GFAP protein levels in the ACC of STZ rats. Moreover, STZ + PBM rats had protein levels of MOR increased 14.7% in the ACC. Interestingly, STZ + PBM rats had a decrease in 70.7% of GluR1 protein level in the ACC. Additionally, PBM decreased 45.5% of GAD65/67 protein levels in the ACC of STZ rats. (AU)

FAPESP's process: 17/25554-0 - Study of the effects of the photobiostimulation on the Schwann cell mitochondrial metabolism in Type 1 Diabetes Mellitus
Grantee:Igor Rafael Correia Rocha
Support type: Scholarships in Brazil - Doctorate